EFFICACY OF SERTRALINE WITH L. METHYL FOLATE AND WITHOUT L. METHYL FOLATE IN THE TREATMENT OF MAJOR DEPRESSIVE DISORDER: A COMPARATIVE STUDY
Main Article Content
Keywords
Sertraline, L. methyl folate, major depressive disorder
Abstract
Background: The objective of this study was to compare the efficacy of Sertraline with L-Methyl folate and without L-Methyl folate in patients with major depressive disorder.
Methods: Total of 160 diagnosed of Major Depressive Disorder of either gender patients were included. All patients were examined clinically, and their demographic and medical history was recorded. The patients were divided into two groups with 80 patients. All the patients were treated with Sertraline with L. methyl folate and without L. methyl folate for 2 months.
Result: The independent t test indicated that antidepressants resulted in a highly significant difference (p-value <0.00001) in the age of patients in Group B (Sertraline 50 mg/day with L. methyl folate 75 mg/day) as compared to Group A: (Sertraline 50 mg/day) (42.25±11.54 vs 38.27±11.48). The chi-square test indicated that “sleep disturbance” improved significantly in treatment groups (p<0.05) for all antidepressant medications at 90 days. The “Weight gain” improved significantly in treatment groups (p<0.05) for all antidepressant medications at 90 days. Percentage 37.5 of symptom “Weight gain” reduction was higher for antidepressant Group A: (Sertraline 50 mg/day).
Conclusion: It was concluded that L-methyl folate with Sertraline was more successful in relieving depression symptoms and function than mono-therapy group led to substantial symptomatic improvement faster and better tolerated than single drug.
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Ali Gul Tunio
Department of Pharmacology, Bibi Asifa Dental College, Shaheed Mohtarma Benazir Bhutto Medical University, Sindh, Pakistan
Ghulam Serwar Shaikh
Department of Biochemistry, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University Larkana, Sindh, Pakistan
Fiaza Shaikh
Department of Physiology, Karachi Institute of Medical Sciences Malir cantt Karachi, Sindh, Pakistan
Aneel Kapoor
Department of Biochemistry, People’s University of Medical and Health Science for Woman Shaheed Benazirabad, Sindh, Pakistan
Abdul Hameed Lanjwani
Department of Biochemistry, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University Larkana, Sindh, Pakistan
Ishfaque Ahmed Mugheri
Department of Biochemistry, University of Sindh Jamshoro
Vinay Kumar Jesrani
Department of Biochemistry, Chandka Medical College, Shaheed Mohtarma Benazir Bhutto Medical University Larkana, Sindh, Pakistan
Ghulam Yaseen Khokhar
Department of Biochemistry, Shah Abdul Latif University Khairpur Mir’s, Sindh, Pakistan
Khalid Hussain Mugheri
Lecturer, College of Pharmacy TUMS Sindh Pakistan