FREQUENCY AND ANTIMICROBIAL SUSCEPTIBILITY PROFILES OF URINARY PATHOGENS

Abstract

Urinary tract infections are among the commonly occurring microbial infections ranked as second frequently occurring infectious disease with 150 million diagnosed cases per year. (1) This study was intended to oversee the occurrence of pathogens isolated from urine cultures along with the anti-microbial susceptibility patterns of most common pathogen obtained in a tertiary care Centre. A retrospective study was conducted in the Microbiology department of Chaudhary Mohammad Akram Research and Training Hospital (CMA), Lahore during the period of March 2021 to December 2021. Urine cultures received during this 10 month period were analyzed and the most common organism isolated along with its susceptibility pattern was assessed. During study period, 200 urine cultures were received, out of which 93 turned out to be positive, making the percentage positivity of 46.5%. Most common organism was E.coli i.e. 43%, followed by Candida species i.e. (17%). E.coli was found in 52.5% of female population. Considering the susceptibility pattern of E.coil, most sensitive options of antibiotics were Nitrofurantoin (87.5%), followed by Imipenem (70%) & Amikicin (62.5%). Most resistant antibiotic options were Ampicillin, Nalidixic acid & Ciprofloxacin (2.5%). 82.5% of E.coli isolates were found to be ESBL producers. This research concluded that patients with UTI are at high risk of developing antibiotic resistance. Uro-pathogens isolated in the present study exhibited highest rate of susceptibility against nitrofurantoin, amikacin and imipenem which can be empirically utilized for treatment of urinary tract infections.