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Asif Islam
Syed Abdullah Haider
Fnu Kirshma
Dr. Osama Bin Zia
Aqib Ahmed
Dr. Muhammad Adeel
Dr Jaisingh Rajput


Chronic ache, Demographic variables, Healthcare cost, Sleep disturbance, Women disorders


Background: Fibromyalgia is characterized by chronic pain affecting approximately 2% to 4% of common population. It is manifested by pervasive pain, cognitive problems, fatigue and sleep disturbances. Fibromyalgia can affect individuals of any age, gender, or ethnicity; however, it is more prevalent in women than in men, and it is typically diagnosed in middle age. ‘

Objectives: We investigated demographic as well as clinical characteristics of fibromyalgia in patients presenting to Rheumatology OPD of Mayo Hospital, Lahore.

Methods: This research was conducted from August 2021 to January 2023, in a metropolitan facility of Mayo Hospital Lahore. Patients who met the 2016 revised fibromyalgia diagnostic criteria were included in the study. Demographic information, medical history, clinical characteristics, and laboratory investigations were recorded for each patient.

Results: A total of 139 fibromyalgia patients were included in the study, having average age of 41.87+10.19 years, 76.95+12.92 Kg was their average weight and 23.72 mean BMI and 94.96% of them were females. Before being diagnosed with fibromyalgia, patients reported extensive pain (100%), fatigue (93.52%) and sleep disturbances (84.17%), headache (82.01%), cognitive difficulties (80.57%) as their most prevalent clinical manifestations.

Conclusion: Fibromyalgia is a prevalent disorder observed in rheumatology clinics, particularly among middle-aged women. Fibromyalgia is manifested by pervasive pain, sleep disturbances, fatigue and cognitive complexes. Early diagnosis and treatment of fibromyalgia can enhance patients' quality of life and reduce healthcare expenditures.

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1. Häuser W, Fitzcharles MA. Facts and myths pertaining to fibromyalgia. Dialogues Clin Neurosci. 2018 Mar;20(1):53-62.
2. Mohsin Z, Asghar A A, Faiq A, et al. (June 22, 2018) Prevalence of Rheumatic Diseases in a Tertiary Care Hospital of Karachi. Cureus 10(6): e2858.
3. Kang JH, Choi SE, Park DJ, Lee SS. Disentangling Diagnosis and Management of Fibromyalgia. J Rheum Dis. 2022;29(1): 4-13.
4. Galvez-Sánchez CM, Reyes del Paso GA. Diagnostic Criteria for Fibromyalgia: Critical Review and Future Perspectives. J Clinic Med. 2020;9(4):1219.
5. Clauw DJ, Arnold LM, Mc Carberg BH; Fibro Collaborative. The science of fibromyalgia. Mayo Clin Proc. 2011 Sep;86(9):907-11.
6. Yam MF, Loh YC, Tan CS, Khadijah Adam S, Abdul Manan N, Basir R. General Pathways of Pain Sensation and the Major Neurotransmitters Involved in Pain Regulation. Int J Mol Sci. 2018 Jul 24;19(8):2164.
7. Gyorfi M, Rupp A, Abd-Elsayed A. Fibromyalgia Pathophysiology. Biomedicines. 2022 Nov 29;10(12):3070.
8. Siracusa R, Paola RD, Cuzzocrea S, Impellizzeri D. Fibromyalgia: Pathogenesis, Mechanisms, Diagnosis and Treatment Options Update. International J Molec Sci. 2021; 22(8):3891.
9. Bellato E, Marini E, Castoldi F, Barbasetti N, Mattei L, Bonasia DE, Blonna D. Fibromyalgia syndrome: etiology, pathogenesis, diagnosis, and treatment. Pain Res Treat. 2012;2012:426130.
10. Yang TY, Chen CS, Lin CL, Lin WM, Kuo CN, Kao CH. Risk for irritable bowel syndrome in fibromyalgia patients: a national database study. Medicine (Baltimore). 2015 Mar;94(10):e616.
11. Qureshi AG, Jha SK, Iskander J, Avanthika C, Jhaveri S, Patel VH, Rasagna Potini B, Talha Azam A. Diagnostic Challenges and Management of Fibromyalgia. Cureus. 2021 Oct 11;13(10):e18692.
12. Kaltsas G, Tsiveriotis K. Fibromyalgia. [Updated 2020 Jan 14]. In: Feingold KR, Anawalt B, Blackman MR, et al., editors. Endotext [Internet]. South Dartmouth (MA):, Inc.; 2000-
13. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Häuser W, Katz RL, Mease PJ, et al. Fibromyalgia diagnostic criteria. Seminars in Arthritis and Rheumatism. 2016;46(30):319-329.
14. Aloush V, Niv D, Ablin JN, Yaish I, Elkayam O, Elkana O. Good pain, bad pain: illness perception and physician attitudes towards rheumatoid arthritis and fibromyalgia patients. Clin Exp Rheumatol. 2021 May-Jun;39 Suppl 130(3):54-60.
15. Pang HY, Farrer C, Wu W, Gakhal NK. Quality of rheumatology care for patients with fibromyalgia and chronic pain syndromes. BMJ Open Qual. 2021 Mar;10(1):e001061.
16. Jiao J, Vincent A, Cha SS, Luedtke CA, Kim CH, Oh TH. Physical trauma and infection as precipitating factors in patients with fibromyalgia [J]. Am J phys Med Rehabil. 2015;94(12):1075–82.
17. Ohta H, Oka H, Usui C, Ohkura M, Suzuki M, Nishioka K. A randomized, double-blind, multicenter, placebo-controlled phase III trial to evaluate the efficacy and safety of pregabalin in Japanese patients with fibromyalgia. Arthritis Res Ther. 2012;14(5):R217.
18. Jiao J, Cheng Z, Wang W, Zhao Y, Jiang Q. Demographic Characteristics and Clinical Features of Fibromyalgia in China: A Cross-Sectional Study. Rheumatol Ther. 2021 Jun;8(2):817-831.
19. Lin L, Xiao Z, Lin S, Chen R, Lin R, Du W. A rural population survey of soft tissue rheumatic pain in Shantou. China Shanxi Med J. 2007;36:678–80.
20. Weiss, J.E., Schikler, K.N., Boneparth, A.D. et al. Demographic, clinical, and treatment characteristics of the juvenile primary fibromyalgia syndrome cohort enrolled in the Childhood Arthritis and Rheumatology Research Alliance Legacy Registry. Pediatr Rheumatol 17, 51 (2019).
21. Mota LMH, Laurindo IMM, Neto LLS. Demographic and clinical characteristics of a cohort of patients with early rheumatoid arthritis. Bras J Rheumatol 2010;50(3):235-48.
22. Winfried Häuser; Hedi Kühn-Becker; Hubertus von Wilmoswky; Margit Settan; Elmar Brähler; Frank Petzke (2011). Demographic and Clinical Features of Patients With Fibromyalgia Syndrome of Different Settings: A Gender Comparison. , 8(2), 116–125.

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