COMPARATIVE STUDY OF EFFECTS OF IBUPROFEN AND DEXIBUPROFEN ON MOUSE LIVER

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Nasir Hussain Hajano
Safdar Ali Ujjan
Sajid Ali
Sanaullah Abbasi
Abdul Majid Ansari
Riaz Hussain Junejo
Ahmed Algazeeri

Keywords

Ibuprofen, Dexibuprofen, Liver, enzyme, Mice

Abstract

Introduction:Ibuprofen (2RS)-1[4-(2-methyl propyl) phenyl] propionic acid. Dexibuprofen [2-(4-isobutylphenyl) propionic acid] is also NSAID, and is an isomer derived from ibuprofen. Liver is main location for excretion, metabolism, maintenance, homoeostasis and body’s performance. Increased concentrations of biochemical markers such as transaminases are indicators for liver damage.


Objective: The purpose of this study was to compare the Ibuprofen and Dexibuprofen to know their adverse effects on the liver.


Methodology: The mice were kept in the clean cages in the animal house of the Department of Zoology, Shah Abdul Latif University Khairpur. They were treated orally with Ibuprofen and Dexibuprofen for 14 days. At the end of experiment, blood samples were collected from control and experimental groups by anesthetizing animals with chloroform. Liver damage was checked by investigating the activity of biochemical marker enzymes by LFT (liver functioning test). The sections of tissues were cut in size of 4-5 micrometer with help of microtome machine at Department of Zoology of Shah Abdul Latif University, Khairpur. When treated groups were compared with the control group, all enzymes (AST, ALT, and ALP) increased in both drug treated groups.


Results: Results were analysed in excel and charts were created. According to the present study, the administration of both Drugs resulted in structural and functional alterations in the liver tissues and elevated levels of these enzymes in the circulation.

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