Comparative study of the possible gastroprotective effect of probiotic (lactobacillus plantarum) and ranitidine on indomethacin induced gastric ulcer in adult male albino rat
Main Article Content
Keywords
Gastric ulcer, Indomethacin, Ranitidine, probiotic, lactobacillus plantarum.
Abstract
Indomethacin is an anti-inflammatory drug which causes peptic ulcers as a result of its complication, For this reason, multiple experimental studies have been performed to search for new agents in order to treat or prevent gastric and duodenal ulcers. Probiotics are live microorganisms, and it has been stated by different studies that these bacteria have antioxidant and anti-inflammatory effects so; the aim of the present study is to compare the gastroprotective potential of probiotic lactobacillus plantarum, versus the anti-ulcer drug (ranitidine), against indomethacin-induced gastric ulcer in rats.
References
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Khoder G., Al-Menhali A. A., Al-Yassir F., Karam S. M. Potential role of probiotics in the management of gastric ulcer. Experim. Therap. Med.2016 (12): 3–17. 10.3892/etm.2016.3293
Ko JS, Yang HR, Chang JY, Seo JK. Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha. World J Gastroenterol. 2007 Apr 7;13(13):1962-5. doi: 10.3748/wjg.v13.i13.1962. PMID: 17461497; PMCID: PMC4146973.
Liu J., Wang F., Luo H., Liu A., Li K., Li C., et al. Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms. Int. Immunopharmacol. 2016 (30): 179–187. 10.1016/j.intimp.2015.11.018
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Panula, P., Chazot, P. L. and Cowart, M. International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev. 2015. 67(3): 601–655.
Pearse A : Histochemistry, Theoretical and Applied. 3rd Ed vol I. 1977. Churchill Livingstone, Lond) .
Şenol K., Özkan M. B., Vural S., Tez M. The role of inflammation in gastric cancer. Inflamm. Cancer. 2014: 235–257. 10.1007/978-3-0348
Siddique, O., Ovalle, A., Siddique, A. S., & Moss, S. F. Helicobacter pylori infection: An update for the internist in the age of increasing global antibiotic resistance. Am. J. Med., 2018(131), 473–479
Suleyman H, Albayrak A, Bilici M, Cadirci E, Halici Z. Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. Inflammation. 2010;33:224–234.
Toljamo K., Niemelä S., Karvonen A. L., Karttunen R., Karttunen T. J. (2011). Histopathology of gastric erosions association with etiological factors and chronicity. Helicobacter. 2011. 16: 444–451. 10.111/j.1523-5378.2011.00871.x
Ugan RA, Un H. The protective roles of butein on indomethacin induced gastric ulcer in mice. Eurasian. J. Med. 2020. (52): 265–270.
Waller D.G., Renwick A.G. and Hillier K. Medical pharmacology and therapeutics, 2nd ed. El Sevier Limited.2005: 347–401.
Wu, Y, Chen, H, Zou, Y, Yi, R, Mu, J, Zhao, X. Lactobacillus plantarum HFY09 alleviates alcohol-induced gastric ulcers in mice via an anti-oxidative mechanism. J Food Biochem. 2021; 45(5):e13726. https://doi.org/10.1111/jfbc.13726
Zhang M, Fan X, Fang B, Zhu C, Zhu J, Ren F. Effects of Lactobacillus salivarius Ren on cancer prevention and intestinal microbiota in 1,2-dimethylhydrazine-induced rat model. J Microbiol. 2015;53:398–405. doi: 10.1007/s12275-015-5046-z.
URL: http://rjms.iums.ac.ir/article-1-1533-en.html
AlKreathy HM, Alghamdi MK, Esmat A. Tetramethylpyrazine ameliorates indomethacin-induced gastric ulcer in rats: Impact on oxidative, inflammatory, and angiogenic machineries. Saudi Pharm J. 2020;28:916–926.
Amandeep K., Robin S., Ramica S. and Sunil K. Peptic ulcer: A review on etiology and pathogenesis. Int Res. J. Pharmacy. 2012. 3(6): ISSN 2230:8407.
Azhari H., Underwood F., King J., Coward S., Shah S., Ng S., et al. The global incidence of peptic ulcer disease and its complications at the turn of the 21st century: a systematic review. J. Can. Assoc. Gastroenterol. 2018 (113): 684–685. 10.1093/jcag.gwy009.036
Cano-Garrido O, Seras-Franzoso J, Garcia-Fruitós E. Lactic acid bacteria: Reviewing the potential of a promising delivery live vector for biomedical purposes. Microb Cell Fact. 2015;14:137. doi: 10.1186/s12934-015-0313-6.
Crouzet L, Rigottier-Gois L, Serror P. Potential use of probiotic and commensal bacteria as non-antibiotic strategies against vancomycin-resistant enterococci. FEMS Microbiol Lett. 2015;362:fnv012. doi: 10.1093/femsle/fnv012.
Drury R and Wallington E: Carleton, s Histological Technique. 4th Ed. Oxford. Univ. Press, New York, Toronto. 1980 p p: 115-119.
El-Saka M, Abo Zeid A, Abou Fard G. Effect of L-citrulline and ranitidine on indomethacin-induced gastric ulcer in male albino wister rats. Bull Egypt Soc Physiol Sci. 2014;34:277–292.
Ferreira Dos Santos T, Alves Melo T, Almeida ME, Passos Rezende R, Romano CC. Immunomodulatory Effects of Lactobacillus plantarum Lp62 on Intestinal Epithelial and Mononuclear Cells. Biomed Res Int. 2016;2016:8404156. doi: 10.1155/2016/8404156. Epub 2016 Jun 30. PMID: 27446958; PMCID: PMC4944036.
Fong, S. Y., Wong, Y. C., Xie, C., & Zuo, Z. Herb-drug interactions between Scutellariae Radix and mefenamic acid: Simultaneous investigation of pharmacokinetics, antiinflammatory effect and gastric damage in rats. J. Ethnopharmacol, 2015. (170): 106–116.
Gambero, A., Becker, T. L., Zago, A. S., De Oliveira, A. F., & Pedrazzoli, J. J. R. Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors. Inflammopharmacology. 2005 (13): 441–454.
Goderska K., Pena S. A., Alarcon T. Helicobacter pylori treatment: antibiotics or probiotics. Appl. Microbiol. Biotechnol. 2018 (102): 1–7. 10.1007/s00253-017-8535-7
Haghshenas B, Abdullah N, Nami Y, Radiah D, Rosli R, Khosroushahi AY. Different effects of two newly-isolated probiotic Lactobacillus plantarum 15HN and Lactococcus lactis subsp. Lactis 44Lac strains from traditional dairy products on cancer cell lines. Anaerobe. 2014;30:51–59. doi: 10.1016/j.anaerobe.2014.08.009.
Hill C, Guarner F, Reid G, Gibson GR, Merenstein DJ, Pot B, Morelli L, Canani RB, Flint HJ, Salminen S, et al. Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol. 2014;11:506–514. doi: 10.1038/nrgastro.2014.66.
Huang Y, Wang J, Quan G, Wang X, Yang L, Zhong L. Lactobacillus acidophilus ATCC 4356 prevents atherosclerosis via inhibition of intestinal cholesterol absorption in apolipoprotein E-knockout mice. Appl Environ Microbiol. 2014;80:7496–7504. doi: 10.1128/AEM.02926-14.
Imhann F., Bonder M. J., Vila A. V., Fu J., Mujagic Z., Vork L., et al. Proton pump inhibitors affect the gut microbiome. Gut Microb. 2017 (65): 740–748. 10.1136/gutnjnl-2015-310376
Jaldani V, Dezfoulian O, Shahsavari G. Betaine improves gastroprotective effects of ranitidine and omeprazole against indomethacin-induced gastric ulcer in rats. Herb Med J. 2017;2:9–17.
Ji Y., Park S., Park H., Hwang E., Shin H., Pot B., et al. Modulation of active gut microbiota by Lactobacillus rhamnosus GG in a diet induced obesity murine model. Front. Microbiol.2018 (9):710 10.3389/fmicb.2018.00710
Khoder G, Al-Menhali AA, Al-Yassir F, Karam SM. Potential role of probiotics in the management of gastric ulcer. Exp Ther Med. 2016 Jul;12(1):3-17. doi: 10.3892/etm.2016.3293. Epub 2016 Apr 26. PMID: 27347010; PMCID: PMC4906699.
Khoder G., Al-Menhali A. A., Al-Yassir F., Karam S. M. Potential role of probiotics in the management of gastric ulcer. Experim. Therap. Med.2016 (12): 3–17. 10.3892/etm.2016.3293
Ko JS, Yang HR, Chang JY, Seo JK. Lactobacillus plantarum inhibits epithelial barrier dysfunction and interleukin-8 secretion induced by tumor necrosis factor-alpha. World J Gastroenterol. 2007 Apr 7;13(13):1962-5. doi: 10.3748/wjg.v13.i13.1962. PMID: 17461497; PMCID: PMC4146973.
Liu J., Wang F., Luo H., Liu A., Li K., Li C., et al. Protective effect of butyrate against ethanol-induced gastric ulcers in mice by promoting the anti-inflammatory, anti-oxidant and mucosal defense mechanisms. Int. Immunopharmacol. 2016 (30): 179–187. 10.1016/j.intimp.2015.11.018
Marchesi JR, Adams DH, Fava F, Hermes GD, Hirschfield GM, Hold G, Quraishi MN, Kinross J, Smidt H, Tuohy KM, et al. The gut microbiota and host health: A new clinical frontier. Gut. 2016;65:330–339. doi: 10.1136/gutjnl-2015-309990.
Panula, P., Chazot, P. L. and Cowart, M. International Union of Basic and Clinical Pharmacology. XCVIII. Histamine Receptors. Pharmacol Rev. 2015. 67(3): 601–655.
Pearse A : Histochemistry, Theoretical and Applied. 3rd Ed vol I. 1977. Churchill Livingstone, Lond) .
Şenol K., Özkan M. B., Vural S., Tez M. The role of inflammation in gastric cancer. Inflamm. Cancer. 2014: 235–257. 10.1007/978-3-0348
Siddique, O., Ovalle, A., Siddique, A. S., & Moss, S. F. Helicobacter pylori infection: An update for the internist in the age of increasing global antibiotic resistance. Am. J. Med., 2018(131), 473–479
Suleyman H, Albayrak A, Bilici M, Cadirci E, Halici Z. Different mechanisms in formation and prevention of indomethacin-induced gastric ulcers. Inflammation. 2010;33:224–234.
Toljamo K., Niemelä S., Karvonen A. L., Karttunen R., Karttunen T. J. (2011). Histopathology of gastric erosions association with etiological factors and chronicity. Helicobacter. 2011. 16: 444–451. 10.111/j.1523-5378.2011.00871.x
Ugan RA, Un H. The protective roles of butein on indomethacin induced gastric ulcer in mice. Eurasian. J. Med. 2020. (52): 265–270.
Waller D.G., Renwick A.G. and Hillier K. Medical pharmacology and therapeutics, 2nd ed. El Sevier Limited.2005: 347–401.
Wu, Y, Chen, H, Zou, Y, Yi, R, Mu, J, Zhao, X. Lactobacillus plantarum HFY09 alleviates alcohol-induced gastric ulcers in mice via an anti-oxidative mechanism. J Food Biochem. 2021; 45(5):e13726. https://doi.org/10.1111/jfbc.13726
Zhang M, Fan X, Fang B, Zhu C, Zhu J, Ren F. Effects of Lactobacillus salivarius Ren on cancer prevention and intestinal microbiota in 1,2-dimethylhydrazine-induced rat model. J Microbiol. 2015;53:398–405. doi: 10.1007/s12275-015-5046-z.
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Dec 12, 2021
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Walid Mostafa Said Ahmed, Ahmed EL Sayed Ahmed Amer, Ebrahim M. M. Fayed, Mohamed Dmerdash, Usama Bhgat El- Gazzar, Doaa Genedy, Moaaz M. Y. Awad. (2021). Comparative study of the possible gastroprotective effect of probiotic (lactobacillus plantarum) and ranitidine on indomethacin induced gastric ulcer in adult male albino rat. Journal of Population Therapeutics and Clinical Pharmacology, 28(2), 237–253. https://doi.org/10.53555/jptcp.v28i2.3704
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