AMELIORATIVE EFFECT OF PEPPERMINT OIL (MENTHA PIPERITA L.) IN LIVER FUNCTION AND SERUM LIPID PEROXIDATION BIOMARKERS IN MALE ALBINO RATS WITH INDUCED NONALCOHOLIC FATTY LIVER DISEASE: A RANDOMIZED CLINICAL CONTROL TRAIL

Abstract

The complexity, diagnosing challenges, and lack of recognized therapies for non-alcoholic fatty liver disease have made it a major problem. It is anticipated that non-alcoholic fatty liver disease (NAFLD) will surpass hepatitis C as the most prevalent chronic liver disease in adults and children over the next ten years. It is also anticipated to emerge as the primary reason for liver transplantation. It coexists with obesity, hypertension, type 2 diabetes mellitus, and dyslipidemia. Current clinical trials have concentrated on a number of disease reasons, and how these treatments fit into the current paradigm of substrate overload lipotoxic liver injury has been addressed here. Many of the approaches concentrate on downstream events such inflammation, damage, and fibro genesis. Many natural therapies are used to combat elevated liver function enzymes and lipid peroxidation in patients of NAFLD.  Mentha piperita L. and M. arvensis var. piperascens, two perennial plants in the Labiatae family, are used to extract peppermint oil from their leaves. Popular and significant, this plant is used extensively for a variety of therapeutic purposes in many indigenous medical systems. These include analgesic, anaesthetic, antiseptic, astringent, carminative, decongestant, expectorant, nervine, stimulant, stomachic, inflammatory diseases, ulcer, and stomach issues. The present study was to highlight the therapeutic effect of peppermint oil against elevated liver enzymes alanine transaminase (ALT) aspartate transaminase,(AST) and melanodialdehyde(MDA).For this purpose the paper mint oil was firstly observed for its chemical composition  afterwards  Thirty (30)male albino rats were induced with induced fatty liver disease by induction of  using the mixture of  high fat and high fructose diet and divide them in equal quantity in equal groups in which control group was G0 was observed as control group was not received and G1 and G2 were observed as treatment group and they were given 30ml and 60 ml of peppermint oil as per kg of their body weight. After that liver enzymes ALT, AST AND MD were measured before and after the trial using ANOVA test. Both treatment groups showed significant reduction in elevated liver enzymes alanine transaminase, and aspartate transaminase. A significant reduction was also seen in lipid peroxidation parameter melanodialdehyde in treatment groups. All results were taken significant art p<0.05.