EVALUATION OF ANTIBIOTIC RESISTANCE PATTERN OF UROPATHOGENS IN PATIENTS WITH URINARY TRACT INFECTION IN A TERTIARY CARE CENTER, NORTH MAHARASHTRA

Main Article Content

Ms Durga Gajanan Mahale
Dr Rahul Chavan

Keywords

antibiotic resistance, Culture, UTI, uropathogens

Abstract

Background: Urinary tract infection (UTI) is one of the most common bacterial infections worldwide affects women more than men. Recently, there has been a changing trend in the pattern of antibiotic resistance amongst uropathogens. It is necessary to create an awareness of regional antibiotic resistance pattern among prescribing doctors.


Method: A retrospective hospital based study conducted at tertiary care centre north Maharashtra between October 2021 and December 2022.  Patients above 18 years of age admitted to with a diagnosis of UTI included in the study. The data regarding causative uropathogens and their antibiotic susceptibility were retrieved from patient’s case record files.


Results: Culture and antibiotic sensitivity reports were analyzed. Out of 120 significant isolates, gram-negative organisms accounted for 80.5% infection. The most predominant uropathogen isolated was E.coli (72.8%) followed by Klebsiella spp (12.2%), Enterococcus (8.4%) and others. E.coli showed high resistance to ampicillin (86 %), ceftriaxone (76.5%), Co-Trimoxazole (45.5%) and  fluoroquinolones (59.1% to 63%); Klebsiella spp, the second most common uropathogen showed high level of resistance with ampicillin (95%), cephalexin (91%), cefuroxime (71%), ceftriaxone (75%) and Nitrofuration (89.2%).  Enterococcus were  highly  resistant  to Tetracycline (92.9%) Ciprofloxacin (85.7%),  Levofloxacin  (81.8%). Where, E.  coli were  highly sensitive  to Amikacin,  Imipenem,  Ertapenam. Klebsiellawere  highly  sensitive  to Meropenem,  Cefoperazone/Sulbactam,  Amikacin. Enterococcuswas  highly  sensitive  to  Linezolid, Teicoplanin, Vancomycin


Conclusions:  Different uropathogens and their antimicrobial resistance are a concern for future treatment options in UTI.

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