Main Article Content

Ms Durga Gajanan Mahale
Dr Rahul Chavan


antibiotic resistance, Culture, UTI, uropathogens


Background: Urinary tract infection (UTI) is one of the most common bacterial infections worldwide affects women more than men. Recently, there has been a changing trend in the pattern of antibiotic resistance amongst uropathogens. It is necessary to create an awareness of regional antibiotic resistance pattern among prescribing doctors.

Method: A retrospective hospital based study conducted at tertiary care centre north Maharashtra between October 2021 and December 2022.  Patients above 18 years of age admitted to with a diagnosis of UTI included in the study. The data regarding causative uropathogens and their antibiotic susceptibility were retrieved from patient’s case record files.

Results: Culture and antibiotic sensitivity reports were analyzed. Out of 120 significant isolates, gram-negative organisms accounted for 80.5% infection. The most predominant uropathogen isolated was E.coli (72.8%) followed by Klebsiella spp (12.2%), Enterococcus (8.4%) and others. E.coli showed high resistance to ampicillin (86 %), ceftriaxone (76.5%), Co-Trimoxazole (45.5%) and  fluoroquinolones (59.1% to 63%); Klebsiella spp, the second most common uropathogen showed high level of resistance with ampicillin (95%), cephalexin (91%), cefuroxime (71%), ceftriaxone (75%) and Nitrofuration (89.2%).  Enterococcus were  highly  resistant  to Tetracycline (92.9%) Ciprofloxacin (85.7%),  Levofloxacin  (81.8%). Where, E.  coli were  highly sensitive  to Amikacin,  Imipenem,  Ertapenam. Klebsiellawere  highly  sensitive  to Meropenem,  Cefoperazone/Sulbactam,  Amikacin. Enterococcuswas  highly  sensitive  to  Linezolid, Teicoplanin, Vancomycin

Conclusions:  Different uropathogens and their antimicrobial resistance are a concern for future treatment options in UTI.

Abstract 51 | PDF Downloads 29


1. Ronald AR, Pattullo AL. The natural history of urinary infection in adults. Med Clin North Am 1991; 75:299 312
2. Ahmed SS, Shariq A, Alsalloom AA, Babikir IH, Alhomoud BN. Uropathogens and their antimicrobial resistance patterns: Relationship with urinary tract infections. Int J Health Sci. 2019;13(2):48-55.
3. Foxman B, Gillespie B, Koopman J, Zhang L, Palin K, Tallman P, Marsh JV, Spear S, Sobel JD, Marty MJ, Marrs CF.Risk factors for second urinary tract infection among college women. Am J Epidemiol. 2000 Jun 15; 151(12):1194-205.
4. Spellberg B, Bartlett JG, Gilbert DN. The future of antibiotics and resistance. N Engl J Med. 2013;368:299–302.
5. Manges AR, Natarajan P, Solberg OD, Dietrich PS, Riley LW: The changing prevalence of drug-resistant Escherichia coli clonal groups in a community: evidence for community outbreaks of urinary tract infections. Epidemiol Infect. 2006, 134 (2): 425-31. 10.1017/S0950268805005005
6. Panayappan L, Babu AS, Davis D, Joseph N, Joshy N, Krishnakumar K.Urinary tract infection: Prescribing pattern of antibiotics at a tertiary care hospital. Asian J Pharm Clin Res. 2017;10(5):255-7.
7. Khatun SA, Shaha S. Prescribing Pattern of Antimicrobials in Urinary Tract Infection at Outpatient Department in a Tertiary Care Hospital in Dhaka. J Enam Med Coll. 2020;10(1):23-6.
8. Chalise A, Kafle B, Sharifi S, Kumar VS, Mahesh NM, Saxena RK,et al. Utilization of antibiotics in patients with urinary tract infections a study. Indo Am J Pharm Res. 2017;7(8):648-55.
9. SobelJD, Kaye D. Urinary tract infections. In: Mandell GL, BennettJE, Dolin R, editors. Mandell, Douglas and Bennett’s principles and practice of infectious diseases. Vol. 1., 7th ed.., Philadelphia, USA: Churchill Livingstone Elsevier Publication; 2010. p. 958 72
10. Karlowsky JA, Jones ME, Thornsberry C, Critchley I, Kelly LJ, Sahm DF. Prevalence of anti microbial resistance among urinary tract pathogens isolated from female outpatients across the US in 1999. Int J Antimicrob Agents. 2001;18:121–127.
11. Hossain A, Hossain SA,Fatema AN, Wahab A, Alam MM, Islam MN, et al. Age and gender-specific antibiotic resistance patterns among Bangladeshi patients with urinary tract infection caused by Escherichia coli. Int J Health Sci. 2020;6(6):e04161
12. Ny S, Edquist P, Dumpis U, Gröndahl-Yli-Hannuksela K, Hermes J, Kling AM, et al. Antimicrobial resistance of Escherichia coli isolates from outpatient urinary tract infections in women in six European countries including Russia. J Glob Antimicrob Resist. 2019;17:25-34.
13. Beyene G, Tsegaye W. Bacterial uropathogens in urinary tract infection and antibiotic susceptibility pattern in jimma university specialized hospital, southwest ethiopia. Ethiop J Health Sci. 2011 Jul;21(2):141-6.
14. Khatri B, Basnyat S, Karki A, Poudel A, Shrestha B. Etiology and antimicrobial susceptibility pattern of bacterial pathogens from urinary tract infection. Nepal Med Coll J. 2012 Jun;14(2):129-32
15. Khameneh ZR, Afshar AT. Antimicrobial susceptibility pattern of urinary tract pathogens. Saudi J Kidney Dis Transpl. 2009 Mar;20(2):251-3.
16. Mandal J, Acharya NS, Buddhapriya D, Parija SC. Antibiotic resistance pattern among common bacterial uropathogens with a special reference to ciprofloxacin resistant Escherichia coli. Indian J Med Res. 2012 Nov;136(5):842-9.
17. Das RN, Chandrashekhar TS, Joshi HS, Gurung M, Shrestha N, Shivananda PG. Frequency and susceptibility profile of pathogens causing urinary tract infections at a tertiary care hospital in western Nepal. Singapore Med J. 2006 Apr;47(4):281-5.
18. Bahadin J, Teo SS, Mathew S. Aetiology of community-acquired urinary tract infection and antimicrobial susceptibility patterns of uropathogens isolated. Singapore Med J. 2011 Jun;52(6):415-20.
19. Bhargavi PS, Gopala Rao TV, Mukkanti K, Dinesh Kumar B, Krishna TP. Increasing emergence of antibacterial resistance mainly in uropathogens:southeast part of India. Int J Microbiol Res. 2010;2(1):1-6
20. Dalela G, Gupta S, Jain DK, Mehta P. Antibiotic resistance pattern in uropathogens at a Tertiary Care Hospital at Jhalawar with special reference to ESβL, AmpC β-Lactamase and MRSA production. J Clin Diagn Res. 2012;6(4):645–51.