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Dr Rahul Chavan
Ms Durga Gajanan Mahale


Fixed dose combination, prescribing pattern, irrational, ATC classification.


Background: Fixed dose combinations (FDCs) have different focal points and drawbacks. Fixed dose combinations (FDC) enhance the efficacy of individual drugs, decrease the chances of drug resistance, improve patient compliance and also decrease the pill burden on the patients. Studying the prescription pattern helps in developing national database which can be used to promote rational use of drugs.

Method: Prescriptions from various Outdoor Patient Department (OPD) during the study period were used for the study. The drugs were classified according to Anatomical Therapeutic Chemical (ATC) classification.

Results:  The highest percentage of FDCs was seen in alimentary tract 35.78, followed by anti infective(20.21%). Among the alimentary drugs maximum number was of antacid combination followed by combination of proton pump inhibitors and prokinetic drugs. In anti-infective group mostly included amoxiclav, norfloxacin-tinidazole, ofloxacin-ornidazole.

Conclusions: A significant number of drugs are being prescribed as FDCs which also includes various irrational combinations.

Abstract 51 | PDF Downloads 41


1. WHO Expert Committee on Specifications for Pharmaceutical Preparations: thirty-ninth report. (WHO technical report series; 929); 2005
2. Kumar V, Gupta N, Kumar KA. A comparision between old and latest systems in DPCO. Int J Pharm Pharm Sci. 2014;6(2):19–20.3
3. Gautam CS, Saha L. Fixed dose drug combinations (FDCs): Rational or irrational: a view point. Bri J Clinical Pharmacol. 2018;65(5):795-6.
4. Nigam M, Fernandes V, Rataboli P. Fixed dose combinationsto prescribe or not to prescribe: a dilemma of medical profession. Int J Basic Clin Pharmacol. 2014;3(1):105–13. doi:10.5455/2319-2003.ijbcp20140212.
5. Gupta YK, Ramachandran SS. Fixed dose drug combinations: Issues and challenges in India. Indian J Pharmacol. 2016; 48:347-9.
6. CDSCO. Policy Guidelines for the Approval of Fixed Dose Combinations (FDCs) in India. 2013.
7. Gupta YK, Ramachandran SS. Fixed dose drug combinations: Issues and challenges in India. Indian J Pharmacol. 2016;48:347-9.
8. Eesha BR, Shanbhag T, Adiga MNS, Shenoy S. Prescription Pattern of Fixed Dose Drug Combination in Tertiary Care Hospital: An Evaluation Study. Biomedical Research. 2009;20(3):176-9.
9. Das B, Sarkar C, Datta A, Bohra S. A study of drug use during pregnancy in a teaching hospital in western Nepal. Pharmacoepidemiol Drug Saf. 2003;12(3):221-5.
10. Upadhyay D, Singh A, Joshi H, Agarwal M, Katyal R. Study of Prescription Patterns of Fixed Dose Combinations Prescribed by Medical Interns. IJBR 2016;7(9):624-8.
11. The gazette of India. Available at: EnhancedSearch.aspx. Accessed 16 October 2018.