SUPPRESSOR OF CYTOKINE SIGNALING MEMBERS IN LUNG ADENOCARCINOMA: UNVEILING EXPRESSION PATTERNS, POSTTRANSLATIONAL MODIFICATIONS, AND CLINICAL SIGNIFICANCE
Main Article Content
Keywords
Lung adenocarcinoma, SOCSs, expression, prognosis, PTMs, therapeutic target
Abstract
The role of SOCS (Suppressor of Cytokine Signaling) members in cancer has garnered significant research interest. However, their specific role in lung adenocarcinoma awaits a recent report utilizing publicly available databases and software. Our analysis included an exploration of overall survival, expressions, correlation patterns, genetic alterations, prognostic values, network analysis, and gene ontology and posttranslational modification insights of SOCS members using bioinformatics tools. Our findings revealed that both SOCS2 and SOCS3 are downregulated in LUAD. Specifically, posttranslational modification analysis indicated that SOCS2 undergoes phosphorylation at serine 30 and ubiquitination at lysine 38. In the case of SOCS3, potential phosphorylation sites were identified at threonine 86 and tyrosine 165, 166, 221, and 204, with evidence of ubiquitination at lysine 6, 23, 195, and 206. We observed that SOCS genes exhibited a moderate net alteration frequency of 20% in LUAD patients. Additionally, a strong pairwise correlation between SOCS2 and SOCS3 was evident. Furthermore, our analysis revealed the integration of SOCS-related genes into kinase activity. Notably, decreased mRNA levels of SOCS1, SOCS3, SOCS4, and SOCS7, along with increased levels of SOCS5 and SOCS6, were significantly associated with longer overall survival. In conclusion, our study suggests that SOCS5 and SOCS6 function as tumor suppressor genes, while SOCS1, SOCS3, SOCS4, and SOCS7 act as tumor promoter genes in LUAD. Furthermore, our findings indicate that SOCS2 may represent a potential therapeutic target, and SOCS3 could serve as a valuable prognostic biomarker for LUAD patients.
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This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
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Martínez Castro Jesús Alberto
Centro de Investigación en Computación, Instituto Politécnico Nacional, Mexico City, Mexico
Tat'y Mwata-Velu
Centro de Investigación en Computación, Instituto Politécnico Nacional, Mexico City, Mexico
Hubert Misonia
Department of Mathematics and Informatics Université Pédagogique Nationale, République Démocratique du Congo
Mpangi Musungu Erick
Department of Mathematics and Informatics Université Pédagogique Nationale, République Démocratique du Congo
Ayesha Qasim
Centro de Investigación en Computación, Instituto Politécnico Nacional, Mexico City, Mexico
Fida Ullah
Centro de Investigación en Computación, Instituto Politécnico Nacional, Mexico City, Mexico
Muhammad Tayyab Zamir
Centro de Investigación en Computación, Instituto Politécnico Nacional, Mexico City, Mexico
Miele Mboma Joachim
Department of Mechanics Institute Supérieur Pédagogique Technique de Kinshasa, République Démocratique du Congo
Juan Gabriel Avina-Cervantes
Department of Electronics and Communication Engineering Universidad de Guanajuato, Mexico
Zahid Ullah
Department of Computing and Software Engineering, Abasyn University Peshawar, Pakistan
Sunga Baruti Jacob
Department of Mathematics and Informatics Université Pédagogique Nationale, République Démocratique du Congo