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Malaria, Protozoan, Vector, Endemic, Prevalence, Plasmodium vivax, Plasmodium falciparum
A mosquito serves as the illness's primary vector, and the genus Plasmodium's intracellular protozoan parasites invade red blood cells to generate the systemic vector-borne disease known as malaria. Due to its potential for fast progression to complications and mortality in the absence of quick and effective treatment, malaria is a medical emergency. The majority of factors that induce severe malaria include Plasmodium falciparum. A female Anopheles mosquito that is feeding infects the human host by injecting the parasites. The four species of Plasmodia that may infect people are P. falciparum, P. vivax, P. ovale, and P. malariae. Among the four species, P. falciparum is the main species that causes severe disease and mortality. The second most lethal illness in the world is malaria. More than 300 million people are infected by the infectious disease each year, and it claims 1.5 to 2.7 million lives. A kid dies from the infectious illness every 30 seconds, or an estimated one million children under the age of five every year. About half of the world's population is at risk from malaria, and more than 1 million children die each year from its consequences. When mosquitoes that contain the malaria parasite bite and infect humans, the disease is spread. Malaria causes low birth weight (below 2500g) in pregnant women who are not treated, which can result in a variety of disabilities such as cerebral palsy, mental retardation, and cognitive deficiencies. In district Mardan this disease is more prevalent in males than females. From pathology Department Mardan medical complex 230 Blood samples were obtained, and thick and thin slides produced of them. for all individuals and studied its microscopy. 23 Positive cases were found out of 230 blood samples. In these 230 blood samples Plasmodium vivax were found 16 (6.9%) and plasmodium falciparum were found 7 (3.04%) and no mix infection was found. In 230 blood samples there were 15 (6.5%) males and 8 (3.4%) females which were infected by malaria parasite. In 15 infected males there were 11 (73.3%) P.vivax and 4 (26.6%) were P.falciparum. Also in 8 infected females there were 5 (62.5%) P.vivax and 3 (37.5%) were P.falciparum. In both males and females P.vivax were found more than P.falciparum. Month wise samples were collected and its prevalence was studied. Different age groups were made and malaria prevalence was studied in them. 5 years or less than 5 years group was not included. Malaria disease was found more in age group from 6 years up to 15 years.
2. REECE, S. E. AND J. THOMPSON, 2008.Transformation of the rodent malaria parasite
3. REITER, P., 2000.From Shakespeare to Defoe: malaria in England in the Little Ice Age. Emerg Infect Dis 6: 1-11.
4. JANSE, C. J., J. RAMESAR AND A. P. WATERS., 2006. High-efficiency transfect ion and drug selection of genetically transformed blood stages of the rodent malaria parasite Plasmodium berghei. Nat Protoc 1: 346-356.
5. WORLD HEALTH ORGANIZATION, 2009.WHO World Malaria Report 2009.In. World Health Organization, pp.
6. . STEKETEE, R.W. AND C.C. CAMPBELL, MALAR J, 2010.Impact of national malaria control scale-up programmes in Africa: magnitude and attribution of effects.
7. CIBULSKIS, R. E., D. BELL, E. M. CHRISTOPHEL, J. HII, C. DELACOLLETTE, N. BAKYAITA AND M. W. AREGAWI., 2007 Estimating trends in the burden of malaria at country level. Am J Trop Med Hyg 77: 133-137
8. LENGELER C., 2004.Insecticide-treated bed nets and curtains for preventing malaria Cochrane Database Syst Rev
9. NAJERA J.A., M. GONZALEZ-SILVA., P. L ALONSO., 2011.Some lessons for the future from the Global Malaria Eradication Programme (1955-1969). PLoS Med.
10. ADAMS, S., H. BROWN AND G. TURNER., 2002b Breaking down the blood-brain barrier: signaling a path to cerebral malaria? Trends Parasitol 18: 360-366.
11. MURTAZA, G., MEMON, I.A., MEMON, A.R., LAL, M.N. AND KALLAR, N.A., 2009. Malaria morbidity in Sindh and the plasmodium species distribution. Pakistan J. med. Sci., 25:646-649.
12. HAYAKAWA, T., N. ARISUE, T. UDONO, H. HIRAI, J. SATTABONGKOT, T. TOYAMA, T. TSUBOI, T. HORII AND K. TANABE, 2009.Identification of Plasmodium malariae, a human malaria parasite, in imported chimpanzees. PLoS One 4: e7412.
13. YAR, H.M., K. MASOOD, A. MAQBOOL AND G.Q. MALIK, 1998. Prevalence of malarial Parasite species in Multan district. The Professional, 5: 183–
14. KRAUSE PJ. BEHRMAN, KLEIGMAN, JENSES. NEELSON 2003. Malaria, Plasmodium In: Textbook of Pediatrics; 17th ed, Philadelephia; W.B Saunder; p. 1049-52.
15. BASCH PF. 1999. Textbook of International Health (2nd Edition). New York: Oxford BHALLI, M.A. AND SAMIULLAH, 2001. Falciparum malaria- a review of 120 cases. J. Coll. Phys. Surg. Pakistan, 11: 300–3
16. NCHINDA TC 1998. Malaria: A Re-emerging disease in Africa. Emerging Infectious Diseases, Vol. 4(3): 398–403.
17. WINCH PJ, MAKEMBA AM, KAMAZIMA SR, LWIHULA GK, LUBEGA P, MINJAS JN AND SHIFF CJ 1994. Seasonal variation in the perceived risk of malaria: implications for the promotion of insecticide-impregnated bed nets. Social Science and Medicine, Vol. 39(1): 63–75.