EFFECTIVENESS OF TOPICAL NANOEMULGEL IN PROMOTING WOUND HEALING

Abstract

Wound healing is a complex and dynamic process involving various cellular and biochemical events. Over the years, researchers have explored innovative approaches to enhance wound healing and reduce the associated complications. One such promising advancement is the utilization of topical nanoemulgels, a combination of nanoemulsion and hydrogel, for promoting wound healing. This review systematically examines the various formulation components and techniques employed in the preparation of nanoemulgels, emphasizing their role in optimizing drug delivery to the wound site. Special emphasis is placed on the role of surfactants, co-surfactants, and polymers in optimizing the formulation to achieve enhanced stability, drug loading capacity, and sustained release profiles. Furthermore, the physicochemical attributes of nanoemulgels, such as particle size, viscosity, and rheological behavior, are dissected in detail. The impact of these properties on drug release kinetics and skin permeation is expounded. Moreover, this review critically assesses the future perspectives and applications of topical nanoemulgels for wound healing applications. In conclusion, this review provides a comprehensive overview of the formulation and evaluation of topical nanoemulgels for wound healing. The integration of nanotechnology with wound care holds promise for revolutionizing treatment strategies, offering faster healing, reduced scarring, and improved overall patient outcomes. Nanoemulgels provides sustain release activity and may be useful in solving the limitations of conventional drug delivery system. Patient compliance will be more because topical administration of these nanoemulgels is less greasy, transparent and comfortably applied on the skin