DEVELOPMENT AND EVALUATION OF SESAMOL LOADED LINUM USITATISSIMUM SEED MUCILAGE BASED MICROSPHERES

Main Article Content

Subhranshu Panda
Umesh Jirole
Santosh Jadhav
Dhanashree Jirole
Vivek Kulkarni

Keywords

Sesamol, Linum usitatissimum, Natural Mucilage, Microspheres, Antihyperlipidemic

Abstract

The mucilages are polysaccharide obtained from various seeds. Thus, present study is started with aim to formulate Linum usitatissimum seed mucilage based microspheres of sesamol. The drug loaded microspheres were formulated using ionic gelation method and evaluated for physicochemical properties. The mucilage showed acceptable colour, odour and taste. The microspheres showed good swelling ability, mucoadhesive potential and sustained drug release. Thus, linseed mucilage could be promising alternative for fabrication of gastroretentive drug delivery system. 

Abstract 66 | pdf Downloads 28

References

Natarajan V, Krithica N, Madhan B, Sehgal PK. Formulation and Evaluation of Quercetin Polycaprolactone Microspheres for the Treatment of Rheumatoid Arthritis. J Pharm Sci. 2011;100:195–205.
2. Boddupalli BM, Ramani R, Subramaniam B, Anisetti RN. In vitro and invivo evaluation of hepato protection and anti ulcer activities of piperine gastro retentive micropspheres. Asian Pac J Trop Biomed [Internet]. Asian Pacific Tropical Biomedical Magazine; 2012;2:S1237–40. Available from: http://dx.doi.org/10.1016/S2221-1691(12)60392-X
3. Trickler WJ, Nagvekar AA, Dash AK. A Novel Nanoparticle Formulation for Sustained Paclitaxel Delivery. AAPS PharmSciTech. 2008. p. 486–93.
4. Amiri MS, Mohammadzadeh V, Ehsan M. Plant-Based Gums and Mucilages Applications in. Molecules. 2021;26:1770.
5. Jiménez RA, Millán D, Suesca E, Sosnik A, Fontanilla MR. Controlled release of an extract of Calendula officinalis flowers from a system based on the incorporation of gelatin-collagen microparticles into collagen I scaffolds : design and in vitro performance. Drug Deliv Transl Res. 2015;5:209–18.
6. Afghah F, Altunbek M, Dikyol C, Koc B. Preparation and characterization of nanoclay-hydrogel composite support-bath for bioprinting of complex structures. Sci Rep [Internet]. Springer US; 2020;10:1–13. Available from: http://dx.doi.org/10.1038/s41598-020-61606-x
7. Rajawat G, Shinde U, Nair H. Chitosan-N-acetyl cysteine microspheres for ocular delivery of acyclovir: Synthesis and in vitro/in vivo evaluation. J Drug Deliv Sci Technol. 2016;35:333–42.
8. Ahmad H, Sehgal S, Mishra A, Gupta R. Mimosa pudica L. (Laajvanti): An overview. Pharmacogn Rev. 2012;6:115–24.
9. Singh K. Evaluation of Mimosa pudica seed mucilage as sustained-release excipient. AAPS Pharm Sci Tech. 2009;10:1121–7.
10. Gunawardhana CB, Ranasinghe SJ, Waisundara VY. Review: Mimosa pudica Linn.: The garden weed with therapeutic properties. Isr J Plant Sci. 2015;62:234–41.
11. Abrar A. Formulation and evaluation of microsphere of antiulcer drug using Acacia nilotica gum. Int J Health Sci (Qassim). 2020;14:10–7.
12. Donato A, Paola C, Nicola F, Salvatore C, Paolino D. Rutin-loaded Chitosan Microspheres: Characterization and Evaluation of the Anti-Inflammatory Activity. Carbohydr Polym [Internet]. Elsevier Ltd.; 2016;152:583–91. Available from:
http://dx.doi.org/10.1016/j.carbpol.2016.06.039
13. Gourishetti K, Keni R, Nayak PG, Jitta SR, Bhaskaran NA, Kumar L, et al. Sesamol-loaded PLGA nanosuspension for accelerating wound healing in diabetic foot ulcer in rats. Int J Nanomedicine. 2020;15:9265–82.
14. Ghumman SA, Mahmood A, Noreen S, Rana M, Hameed H, Ijaz B, et al. Formulation and evaluation of quince seeds mucilage – sodium alginate microspheres for sustained delivery of cefixime and its toxicological studies. Arab J Chem. Elsevier; 2022;15:103811