PREVALENCE OF ORAL MUCOSAL LESIONS IN NON-ORAL HABIT DIABETIC PATIENTS AND NORMAL SUBJECTS
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Abstract
Background: - The association between diabetic mellitus and oral mucosal lesions, especially oral lichen planus has been the subject of much research but conclusion is controversial. The reported frequency of oral lichen planus in diabetes mellitus varies from 1.6% to 85%
Objective: - prevalence of oral mucosal lesions in non-oral habit diabetic patients and normal subjects
Materials And Method: - Cross sectional study involving 200 diabetic and 200 non diabetic control subjects without any oral habits. Detailed oral examination was performed based on international criteria.
Results: - A significantly greater proportion of subjects with DM(46%) had one or more OML in comparison to non- diabetics(30%) patients. Patients with DM showed significantly greater prevalence of oral lichen planus, geographical tongue, denture stomatitis and angular cheilitis (p<0.05).
Conclusions: - prevalence of OML was significantly higher in diabetic patients than non-diabetic
References
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26. B. Feldt-Rasmussen, The development of nephropathy in insulin-dependent diabetes mellitus is associated with poor glycemic control, Transplant. Proc. 26 (1994) 371–372.
27. L.M. Sykes, A. Sukha, Potential risk of serious oral infections in the diabetic patient: a clinical report, J. Prosthet. Dent. 86 (2001) 569–573.
28. M. Albrecht, J. Banoczy, E. Dinya, G. Tamas Jr., Occurrence of oral leukoplakia and lichen planus in diabetes mellitus, J. Oral Pathol. Med. 21 (1992) 364–366.
29. D. Grinspan, J. Diaz, L. Villapol, J. Scheineiderman, R.Berdichesky, D. Palese, et al., Lichen ruber planus de la muqueuse buccale. Son associaton a´ un diabete, Bull. Soc. Franc¸aise de Dermatologie et de Syphiligraphie 73 (1966) 898–899.
30. M.A. Romero, J. Seoane, P. Varela-Centelles, P. Diz-Dios, M.J. Garcia-Pola, Prevalence of diabetes mellitus amongst oral lichen planus patients. Clinical and pathologicalcharacteristics, Med. Oral 7 (2002) 121–129.
31. J. Gibson, P.J. Lamey, M. Lewis, B. Frier, Oral manifestations of previously undiagnosed non-insulin dependent diabetes mellitus, J. Oral Pathol. Med. 19 (1990) 284–287.
32. I.M. Lundstrom, Incidence of diabetes mellitus inpatients with oral lichen planus, Int. J. Oral Surg. 12 (1983) 147–152.
33. R.F. Borghelli, I.L. Pettinari, J.A. Chuchurru, M.A. Stirparo, Oral lichen planus in patients with diabetes. An epidemiologic study, Oral Surg. Oral Med. Oral Pathol. 75 (1993) 498–500.
34. J.L. Xue, M.W. Fan, S.Z. Wang, X.M. Chen, Y. Li, L. Wang, A clinical study of 674 patients with oral lichen planus in China, J. Oral Pathol. Med. 34 (2005) 467–472.
35. I. Al-Hashimi, M. Schifter, P.B. Lockhart, D. Wray, M. Brennan, C.A. Migliorati, et al., Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 103 (Suppl.) (2007), S25 e1–12
2. A. Zaini, Where is Malaysia in the midst of the Asian epidemic of diabetes mellitus? Diabetes Res. Clin. Pract. 5 (2000) S23–S28.
3. G.M. Leung, K.S. Lam, Diabetic complications and their implications on health care in Asia, Hong Kong Med. J. 6 (2000) 61–68.
4. I.B. Lamster, E. Lalla, W.S. Borgnakke, G.W. Taylor, The relationship between oral health and diabetes mellitus, J. Am. Dent. Assoc. 139 (Suppl.) (2008) 19S–24S.
5. F.J. Silvestre, L. Miralles, F. Llambes, D. Bautista, E. Sola- Izquierdo, A. Hernandez-Mijares, Type 1 diabetes mellitus and periodontal disease: relationship to different clinical variables, Med. Oral Patol. Oral Cir. Bucal. 14 (2009) E175–E179.
6. G. Kaur, B. Holtfreter, W.G. Rathmann, C. Schwahn, H. Wallaschofski, S. Schipf, et al., Association between type 1 and type 2 diabetes with periodontal disease and tooth loss, J. Clin. Periodontol. 36 (2009) 765–774.
7. D.J. Zegarelli, Fungal infections of the oral cavity, Otolaryngol. Clin. North Am. 26 (1993) 1069–1089.
8. G.P. Wysocki, T.D. Daley, Benign migratory glossitis inpatients with juvenile diabetes, Oral Surg. Oral Med. Oral Pathol. 63 (1987) 68–70.
9. J. Guggenheimer, P.A. Moore, K. Rossie, D. Myers, M.B. Mongelluzzo, H.M. Block, et al., Insulin-dependent diabetes mellitus and oral soft tissue pathologies. II. Prevalence and characteristics of candida and candidal lesions, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 89 (2000) 570–576.
10. E. Dorko, Z. Baranova, A. Jenca, P. Kizek, E. Pilipcinec, L. Tkacikova, Diabetes mellitus and candidiases, Folia Microbiol. (Praha) 50 (2005) 255–261.
11. F. Cairo, R. Rotundo, G. Frazzingaro, L. Muzzi, G.P. Pini Prato, Diabetes mellitus as a risk factor for periodontitis, Minerva Stomatol. 50 (2001) 321–330.
12. J. Guggenheimer, P.A. Moore, K. Rossie, D. Myers, M.B. Mongelluzzo, H.M. Block, et al., Insulin-dependent diabetes mellitus and oral soft tissue pathologies. I. Prevalence and characteristics of non-candidal lesions, Oral Surg. OralMed. Oral Pathol. Oral Radiol. Endod. 89 (2000) 563–569.
13. M.R. Quirino, E.G. Birman, C.R. Paula, Oral manifestations of diabetes mellitus in controlled and uncontrolled patients, Braz. Dent. J. 6 (1995) 131–136.
14. M. Valko, D. Leibfritz, J. Moncol, M.T. Cronin, M. Mazur, J. Telser, Free radicals and antioxidants in normal\ physiological functions and human disease, Int. J. Biochem. Cell Biol. 39 (2007) 44–84.
15. M. Ujpal, O. Matos, G. Bibok, A. Somogyi, G. Szabo, Z. Suba, Diabetes and oral tumors in Hungary: epidemiological correlations, Diabetes Care 27 (2004) 770–774.
16. M. Ujpal, O. Matos, G. Bibok, G. Szabo, Incidence of diabetes mellitus in patients with malignant tumors of the oral cavity, Orv. Hetil. 143 (2002) 2731–2733.
17. R.P. Dikshit, K. Ramadas, M. Hashibe, G. Thomas, T. Somanathan, R. Sankaranarayanan, Association between diabetes mellitus and pre-malignant oral diseases: a cross sectional study in Kerala, India, Int. J. Cancer 118 (2006) 453–457.
18. C. Petrou-Amerikanou, A.K. Markopoulos, M. Belazi, D. Karamitsos, P. Papanayotou, Prevalence of oral lichen planus in diabetes mellitus according to the type of diabetes, Oral Dis. 4 (1998) 37–40.
19. M.L. Van Dis, E.T. Parks, Prevalence of oral lichen planus in patients with diabetes mellitus, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 79 (1995) 696–700.
20. I.R. Kramer, J.J. Pindborg, V. Bezroukov, J.S. Infirri, Guide to epidemiology and diagnosis of oral mucosal diseases and conditions. World Health Organization, Commun. Dent. Oral Epidemiol. 8 (1980) 1–26.
21. H.L. Collin, L. Niskanen, M. Uusitupa, J. Toyry, P. Collin, A.M. Koivisto, et al., Oral symptoms and signs in elderly patients with type 2 diabetes mellitus. A focus on diabetic neuropathy, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 90 (2000) 299–305.
22. G.W. Taylor, B.A. Burt, M.P. Becker, R.J. Genco, M. Shlossman, W.C. Knowler, et al., Severe periodontitis and risk for poor glycemic control in patients with non-insulindependent diabetes mellitus, J. Periodontol. 67 (1996) 1085– 1093.
23. J.A. Vazquez, J.D. Sobel, Fungal infections in diabetes, Infect. Dis. Clin. North Am. 9 (1995) 97–116. 21 (2006) 177–182.
24. M.W. Brands, T.E. Hopkins, Poor glycemic control induces hypertension in diabetes mellitus, Hypertension 27 (1996) 735–739.
25. P. Bytzer, N.J. Talley, J. Hammer, L.J. Young, M.P. Jones, M. Horowitz, GI symptoms in diabetes mellitus are associated with both poor glycemic control and diabetic complications, Am. J. Gastroenterol. 97 (2002) 604–611.
26. B. Feldt-Rasmussen, The development of nephropathy in insulin-dependent diabetes mellitus is associated with poor glycemic control, Transplant. Proc. 26 (1994) 371–372.
27. L.M. Sykes, A. Sukha, Potential risk of serious oral infections in the diabetic patient: a clinical report, J. Prosthet. Dent. 86 (2001) 569–573.
28. M. Albrecht, J. Banoczy, E. Dinya, G. Tamas Jr., Occurrence of oral leukoplakia and lichen planus in diabetes mellitus, J. Oral Pathol. Med. 21 (1992) 364–366.
29. D. Grinspan, J. Diaz, L. Villapol, J. Scheineiderman, R.Berdichesky, D. Palese, et al., Lichen ruber planus de la muqueuse buccale. Son associaton a´ un diabete, Bull. Soc. Franc¸aise de Dermatologie et de Syphiligraphie 73 (1966) 898–899.
30. M.A. Romero, J. Seoane, P. Varela-Centelles, P. Diz-Dios, M.J. Garcia-Pola, Prevalence of diabetes mellitus amongst oral lichen planus patients. Clinical and pathologicalcharacteristics, Med. Oral 7 (2002) 121–129.
31. J. Gibson, P.J. Lamey, M. Lewis, B. Frier, Oral manifestations of previously undiagnosed non-insulin dependent diabetes mellitus, J. Oral Pathol. Med. 19 (1990) 284–287.
32. I.M. Lundstrom, Incidence of diabetes mellitus inpatients with oral lichen planus, Int. J. Oral Surg. 12 (1983) 147–152.
33. R.F. Borghelli, I.L. Pettinari, J.A. Chuchurru, M.A. Stirparo, Oral lichen planus in patients with diabetes. An epidemiologic study, Oral Surg. Oral Med. Oral Pathol. 75 (1993) 498–500.
34. J.L. Xue, M.W. Fan, S.Z. Wang, X.M. Chen, Y. Li, L. Wang, A clinical study of 674 patients with oral lichen planus in China, J. Oral Pathol. Med. 34 (2005) 467–472.
35. I. Al-Hashimi, M. Schifter, P.B. Lockhart, D. Wray, M. Brennan, C.A. Migliorati, et al., Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations, Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 103 (Suppl.) (2007), S25 e1–12
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Dec 14, 2022
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Dr Zahoor Ahmad Bhat, Dr Anum Maqbool, & Dr (Prof.) Altaf Hussain Chalkoo. (2022). PREVALENCE OF ORAL MUCOSAL LESIONS IN NON-ORAL HABIT DIABETIC PATIENTS AND NORMAL SUBJECTS. Journal of Population Therapeutics and Clinical Pharmacology, 29(04), 638–643. https://doi.org/10.53555/jptcp.v29i04.2933
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Author Biographies
Dr Zahoor Ahmad Bhat
Post Graduate Student, Dept. of Oral Medicine and Radiology, GDC, Srinagar, Jammu and Kashmir, India
Dr Anum Maqbool
Post Graduate Student, Dept. of conservative dentistry and endodontics, GDC, Srinagar, Jammu and Kashmir, India
Dr (Prof.) Altaf Hussain Chalkoo
Prof. and Head, Dept. of Oral Medicine and Radiology, GDC, Srinagar, Jammu and Kashmir, India