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Paternal alcohol exposure, fetal effect, post -natal effects, transgenerational effects
To further elucidate the possible effects of paternal alcohol exposure on fetal and post-natal development, Lee et al. conducted an experimental animal study from which potential transgenerational consequences of paternal alcohol exposure on mouse offspring were explored. The authors concluded that paternal alcohol consumption likely poses some risk to those developing offspring.
However, the authors’ analysis of the incidence of fetal abnormalities may be misleading. The incidence of abnormality for each treatment group was calculated by dividing the number of abnormalities by the total number of dame s. This approach to presenting the data is misrepresentative, because if a dame were carrying one abnormally developed fetus out of a litter of, say, 16, the entire litter would be captured as an “abnormality” in the calculation of incidence.
2. Abel EL. Rat offspring sired by males treated with alcohol. Alcohol 1993;10:237- 242.
3. Tanaka H, Suzuki N, Arima M. Experimental studies on the influence of male alcoholism on fetal development. Brain Dev 1982;4:1- 6.
4. Abel EL. Paternal alcohol consumption affects grooming response in rat offspring. Alcohol 1991;8:21- 23.
5. Ledig M, Misslin R, Vogel E, et al. Paternal alcohol exposure: developmental and behavioral effects on the offspring of rats. Neuropharmacology 1998;37:57- 66.
6. Lee HJ, Ryu J -S, Choi NY, et al. Transgenerational effects of paternal alcohol exposure in mouse offspring . Anim Cells Syst 2013;17:429- 434.
7. Houchi H, Warnault V, Barbier E, et al. Involvement of A2A receptors in anxiolytic, locomotor and motivational properties of ethanol in mice. Genes Brain Behav 2008;7:887- 898.