CANCER IMMUNIZATION WILL THIS TURN OUT TO BE A PLUS? IMMEDIATELY GRASPABLE

Main Article Content

Dr Sahib Sharma
Dr Reshma Dodwad
Dr. Anupama Vithal Kumar Betigeri
Dr Kanwar Shabaz Singh Sandhu
Dr Avineet Kaur
Mehraab Dhillon

Keywords

Lung cancer vaccine, Oral cancer vaccine, Human papillomavirus (HPV) vaccine, and other cancer vaccines

Abstract

The first cancer vaccine using tumor cells and lysates was created in 1980. The COVID-19 pandemic has revitalized interest in cancer vaccines and accelerated their development. Finally, mRNA vaccines can be made rapidly and affordably. RNA-stimulated dendritic cells were the focus of the first mRNA-based cancer vaccine study, which was conducted in 1996. Clinical trials of several cancer immunotherapy vaccines have shown encouraging results. Therapeutic cancer vaccine efficacy is affected by several factors, such as the selected target antigen(s), the presence of adjuvants, and the vaccine's capacity to elicit antitumor T cell responses in a highly immunosuppressive tumor microenvironment.

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References

1. Liu J, Fu M, Wang M, Wan D, Wei Y, Wei X. Cancer vaccines as promising immuno-therapeutics: platforms and current progress. Journal of Hematology & Oncology. 2022;15(1).
2. Lorentzen CL, Haanen JB, Met Özcan, Svane IM. Clinical advances and ongoing trials of mRNA vaccines for cancer treatment. The Lancet Oncology. 2022;23(10).
3. Fritah H, Rovelli R, Chiang CL-L, Kandalaft LE. The current clinical landscape of personalized cancer vaccines. Cancer Treatment Reviews. 2022;106:102383.
4. Lin MJ, Svensson-Arvelund J, Lubitz GS, Marabelle A, Melero I, Brown BD, Brody JD. Cancer vaccines: the next immunotherapy frontier. Nature Cancer. 2022;3(8):911-26.
5. Pardoll DM. Cancer vaccines. Immunology Today. 1993;14(6):310-6.
6. Lavelle EC, Ward RW. Mucosal vaccines — fortifying the frontiers. Nature Reviews Immunology. 2021;22(4):236-50.
7. Schlom J, Arlen PM, Gulley JL. Cancer Vaccines: Moving Beyond Current Paradigms. Clinical Cancer Research. 2007;13(13):3776-82.
8. García-Pardo M, Gorria T, Malenica I, Corgnac S, Teixidó C, Mezquita L. Vaccine Therapy in Non-Small Cell Lung Cancer. Vaccines. 2022;10(5):740.
9. Kitagawa K, Tatsumi M, Kato M, Komai S, Doi H, Hashii Y, Katayama T, Fujisawa M, Shirakawa T. An oral cancer vaccine using a Bifidobacterium vector suppresses tumor growth in a syngeneic mouse bladder cancer model. Molecular Therapy - Oncolytics. 2021;22:592-03.
10. Nielsen KJ, Jakobsen KK, Jensen JS, Grønhøj C, Von Buchwald C. The Effect of Prophylactic HPV Vaccines on Oral and Oropharyngeal HPV Infection—A Systematic Review. Viruses. 2021;13(7):1339.
11. Türeci Özlem, Löwer M, Schrörs B, Lang M, Tadmor A, Sahin U. Challenges towards the realization of individualized cancer vaccines. Nature Biomedical Engineering. 2018;2(8):566-9.
12. Palucka K, Ueno H, Banchereau J. Recent Developments in Cancer Vaccines. The Journal of Immunology. 2011;186(3):1325-31.

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