ANTIOXIDANT EFFECT OF DIFFERENT PARTS OF CASSIA AURICULATA IN STREPTOZOTOCIN INDUCED DIABETIC RATS
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Keywords
antioxidants, Cassia auriculta flower buds extract, Cassia auriculta leaf extract, lipid peroxidation
Abstract
Diabetes is a common chronic disease where therapeutics innovation is much needed. The search for novel antidiabetic molecules can be greatly facilitated by high throughput metabolomic characterization of herbal medicines. Cassia auriculata is a shrub used in ayurvedic medicine and native to India. Oral administration of Cassia auriculta flower buds extract (CFBEt), leaf extract (CLEt) and seeds extract (CSEt) of diabetic rats for 45 days resulted in significant reduction in blood glucose and significant increase in plasma insulin levels. In addition, CFBEt, CLEt and CSEt caused significant increase in the activities of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, reduced glutathione, vitamin C and vitamin E in liver and kidney of diabetic rats with significant decrease in thiobarbituric acid reactive substances (TBARS) and hydroperoxides formation in liver and kidney, suggesting its role in protection against lipid peroxidation induced membrane damage. The antidiabetic and antioxidant effects of CFBEt are more potent than those of CLEt, CSEt and glibenclamide.
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Murugan P
Principal (i/c), Assistant professor in Biochemistry, Faculty of Science, Bharathidhasn University Model College, Vedharanyam-614810, Tamil Nadu, India.
Jawahar S
Assistant professor of Agronomy, Faculty of Agriculture, Annamalai University, Annamalai nagar-608002, Tamil Nadu, India