A NARRATIVE REVIEW ON SARS-COV-2 INFECTION IN PEDIATRICS: CONCERNS, CHALLENGES, MANAGEMENT, AND MITIGATION STRATEGIES
Main Article Content
Keywords
Children, Infants, Health concerns, Coronavirus, therapeutic targets, mutations
Abstract
The coronavirus disease (COVID-19) is a viral respiratory disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The COVID-19 infection in pediatric population has not been studied much because of the comparatively less number of cases among children during COVID- 19 pandemic. As less number of cases in pediatric population has been documented, less is known
about the epidemiology of virus among children. However, the other coronaviruses are comparatively more understood. As the SARS-CoV-2 has progressed, the mutations have been occurred and reported. The current study explores mutants’ infection in infants and children, as well as concerns, problems, management, and mitigation measures based on therapeutic targets of the virus. The articles
were searched using keywords (COVID-19 among children, SARS-CoV-2 infection among children, pediatric infections, coronavirus therapies for children, therapeutic management of hospitalized pediatric patients) from Google scholar, PubMed, Scopus, MDPI and Web of Science data bases. The most important outcomes and clinical features of viral infections in children and adolescents were
studied. The current study also explores the rate of infection, clinical manifestations, clinical findings, and transmission dynamics for SARS-CoV-2 in children. Drug repositioning might be the sole answer to the outbreak of unexpected contagious illnesses because of the delayed mechanism of new drug expansion. The current review systematically compared the proteins expressed by the SARS-CoV-2
genes to those produced by other coronaviruses. This research will also provide novel lead compounds and targets for additional SARS-CoV-2 in both in-vitro and in-vivo investigations. The new insights for medications already in clinical trials, and possibly new drug repositioning techniques will be known to treat SARS-CoV-2 infections in more better ways.
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Jul 13, 2023
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Ali A. Rabaan, Fatimah S. Alshahrani, Muhammad A. Halwani, Majed S. Nassar, Muhammed A. Bakhrebah, Wesam H. Abdulaal, Mohammed Garout, Hatem M. Alhani, Shamsah H. Al-Ahmed, Maha A. Al-Mozaini, Meshal K. AlFonaisan, Sana A. Alshaikh, Abdulnasir M. Alotaibi, Huseyin Tombuloglu, David Chinaecherem Innocent, & Kirnpal Kaur Banga Singh. (2023). A NARRATIVE REVIEW ON SARS-COV-2 INFECTION IN PEDIATRICS: CONCERNS, CHALLENGES, MANAGEMENT, AND MITIGATION STRATEGIES. Journal of Population Therapeutics and Clinical Pharmacology, 30(17), 187–205. https://doi.org/10.47750/jptcp.2023.30.17.016
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Author Biographies
Ali A. Rabaan
Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia
Fatimah S. Alshahrani
Department of Internal Medicine, College of Medicine, King Saud University, Riyadh 11362, Saudi Arabia
Muhammad A. Halwani
Department of Medical Microbiology, Faculty of Medicine, Al Baha University. Al Baha 4781, Saudi Arabia
Majed S. Nassar
Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST) Riyadh 11442, Saudi Arabia
Muhammed A. Bakhrebah
Life Science and Environment Research Institute, King Abdulaziz City for Science and Technology (KACST) Riyadh 11442, Saudi Arabia
Wesam H. Abdulaal
Department of Biochemistry, Faculty of Science, Cancer and Mutagenesis Unit, King Fahad Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia
Mohammed Garout
Department of Community Medicine and Health Care for Pilgrims, Faculty of Medicine, Umm Al-Qura University, Makkah 21955, Saudi Arabia
Hatem M. Alhani
Department of Pediatric Infectious Disease, Maternity and Children Hospital, Dammam 31176, Saudi Arabia
Shamsah H. Al-Ahmed
Specialty Paediatric Medicine, Qatif Central Hospital, Qatif 32654, Saudi Arabia
Maha A. Al-Mozaini
Immunocompromsised Host Research Section, Department of Infection and Immunity, King Faisal, Specialist Hospital and Research centre, Riyadh 11564, Saudi Arabia
Meshal K. AlFonaisan
Basic Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia
Sana A. Alshaikh
Diagnostic Virology laboratory, Maternity and Children Hospital, Eastern Health Cluster, Dammam 32253, Saudi Arabia
Abdulnasir M. Alotaibi
Pediatric Infectious Diseases, Women and Children’s Health Institute, Johns Hopkins Aramco Healthcare, Dhahran 31311, Saudi Arabia
Huseyin Tombuloglu
Department of Genetics Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 34221, Saudi Arabia
David Chinaecherem Innocent
Department of Public Health, Federal University of Technology, Owerri 460114, Imo State Nigeria
Kirnpal Kaur Banga Singh
Department of Medical Microbiology and Parasitology, School of Medical Sciences, Health Campus, Universiti Sains Malaysia, 16150 Kubang Kerian, Kelantan, Malaysia