NEONATAL RECURRENT PROLONGED HYPOTHERMIA ASSOCIATED WITH MATERNAL MIRTAZAPINE TREATMENT DURING PREGNANCY

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Nir Sokolover
Neonatal Intensive Care, Schneider Children’s Medical Center of Israel, Petah Tiqva, Israel

Paul Merlob Merlob
Neonatal Intensive Care, Schneider Children’s Medical Center of Israel, Petah Tiqva, Israel, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Gil Klinger
Neonatal Intensive Care, Schneider Children’s Medical Center of Israel, Petah Tiqva, Israel; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

Keywords

Mirtazapine, hypothermia, newborn

Abstract

We present  a case of recurrent  hypothermia  in concordant  monozygotic  twins  born to a mirtazapine treated mother. The twins were born at 35 weeks gestation at birth weights of 2426 g and 2355 g. Both twins presented with recurrent hypothermia continuing until day 10 of life. Possible etiologies of hypothermia were excluded. The degree of prematurity and the weight of the twins were not consistent with prolonged  thermal  instability.  The twins' mother  was treated  with mirtazapine  during the entire pregnancy.  Due to its serotonin  and alpha 2 receptors  antagonism  mirtazapine  is known to influence thermoregulation in adult humans and other mammals. We suggest that maternal mirtazapine treatment during pregnancy was associated with recurrent hypothermia in both identical twins.

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Dec 8, 2018

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How to Cite
Sokolover, N., Merlob, P. M., & Klinger, G. (2018). NEONATAL RECURRENT PROLONGED HYPOTHERMIA ASSOCIATED WITH MATERNAL MIRTAZAPINE TREATMENT DURING PREGNANCY. Journal of Population Therapeutics and Clinical Pharmacology, 15(2). Retrieved from https://jptcp.com/index.php/jptcp/article/view/217
Issue
Vol. 15 No. 2 (2008)
Section
Articles
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