ALCOHOL: A PHARMACEUTICAL AND PHARMACOLOGICAL POINT OF VIEW DURING LACTATION

Main Article Content

P.G.J. ter Horst
Mitko Madjunkov
Shahnaz Chaudry

Keywords

A lcohol, lactation, breastfeeding, pharmaceutical exposure

Abstract

Background


A safe amount of alcohol that can be ingested by suckling infants is not known. As a result, alcohol consumption by lactating mothers during this crucial time can potentially harm infants.


Objective


This article provides an overview of alcohol pharmacokinetics and pharmacodynamics in breast milk.


Methods/Discussion


This paper reviews literature on alcohol exposure as it relates to suckling infants. Intended and unintended alcohol exposure through breast milk may occur by skin contact, inhalation and by use of alcohol co-formulated drugs. A method for calculating the time to alcohol eli mination from breast milk is also discussed.


Summary


As there is no evidence on a safe amount of alcohol in breast milk, alcohol exposure throughout lactation should be avoided, to ensure the welfare of suckling infants.

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References

1. Grant, WM. Toxicology of the Eye. 3rd ed. Springfield, IL: Charles C. Thomas Publisher, 1986.
2. Brunton LL, Chabner BA, Knollmann BC. Goodman and Gilman's The Pharmacological Basis of Therapeutics. 12th ed. New York, NY: McGraw -Hill, 2011.
3. American Medical Association, Department of Drugs. Drug Evaluations. 6th ed. Chicago, Ill: American Medical Association, 1986.
4. Sweetman SC (editor ). Martindale -The complete drug reference. 35th ed. London: The Pharmaceutical Press, 2007.
5. Martino E, Murtas ML, Loviselli A, et al. Percutaneous intranodular ethanol injection for treatment of autonomously functioning thyroid nodules. Surgery 1992;112(6):1161- 4.
6. Abel EL. Pharmacology of alcohol relating to pregnancy and lactation. Buffalo, NY: Plenum Press; 1984. p. 29- 45.
7. Mennella JA, Beauchamp GK. The transfer of alcohol to human milk. Effects on flavor and the infant's behavior. N Engl J Med 1991;325:981- 5.
8. Menella JA, Garcia -Gomez PL. Sleep disturbances after acute exposure to alcohol in mothers’ milk. Alcohol 2001; 25:153- 158.
9. Hale TW. Medications and mothers’ milk 16th ed 2014. Hale Publishing, Amarillo, USA.
10. Ho E, Collantes A, Kapur BM, Moretti M, Koren G. Alcohol and breast feeding: calculation of time to zero level in milk. Biol Neonate 2001;80(3):219- 22.
11. Dumas -Campagna J, Tardif R, Charest -Tardif G, Haddad S. Ethanol toxicokinetics resulting from inhalation exposure in human volunteers and toxicokinetic modeling. Inhal Toxicol 2014 Feb;26(2):59- 69.
12. Health Council of the Netherlands. Ethanol (ethyl alcohol); Evaluation of the health effects from occupational exposure. The Hague: Health Council of the Netherlands, 2006; publication no. 2006/06OSH. ISBN 90- 5549- 601- 4]
13. Jones AW. Biochemical and physiological research on the disposition and fate of ethanol in the body. In Medico legal aspects of alcohol, 5th edition, Lawyers and Judges publishing company, Tucson 2008.
14. Magnus MC, DeRoo LA, Håberg SE, et al. Prospective study of maternal alcohol intake during pregnancy or lactation and risk of childhood asthma: the Norwegian Mother and Child Cohort Study. Alcohol Clin Exp Res 2014 Apr;38(4):1002- 11.
15. Little RE, Northstone K, Golding J. Alcohol, breastfeeding, and development at 18 months. Pediatrics 2002 May; 109(5):e 72- 2.
16. Little RE, Anderson KW, Ervin CH, Worthington -Roberts B, Clarren SK. Maternal alcohol use during breast -feeding and infant mental and motor development at one year. N Engl J Med 1989 Aug 17;321(7):425- 30.
17. Chan L-N, Anderson GD. Pharmacokinetic and pharmacodynamic interactions of alcohol.Clinical Pharmacokinetics 2014;53:1115-36.