Comparative cytotoxic effect of Acacia nilotica and its mediated strontium nanoparticles

Prateek Veerendrakumar S; Rajeshkumar S; T Lakshmi; A Jayasree

doi:10.47750/jptcp.2023.30.13.011

Prateek Veerendrakumar S

Department of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600 077, India

Rajeshkumar S

Professor , Nanobiomedicine Lab, Centre for Transdisciplinary Research, Dept. Of Pharmacology, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, TN

T Lakshmi

Nanobiomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai – 600077, India

A Jayasree

Nanobiomedicine Lab, Department of Pharmacology, Saveetha Dental College and Hospitals, SIMATS, Saveetha University, Chennai – 600077, India

Keywords

cytotoxic effect , Acacia nilotica, strontium nanoparticles

Abstract

Background: Vachellia nilotica, all the more generally known as Acacia nilotica This plant is hostile to microbial, against plasmodial and cancer prevention agent movement and utilized for therapy of human immunodeficiency infection, hepatitis C infection and malignant growth. A medication or substance that decreases irritation (redness, enlarging, and torment) in the body. Calming specialists block specific substances in the body that cause irritation. They are utilized to treat various circumstances. A few calming specialists are being concentrated on in the counteraction and therapy of disease.
Aim: The aim of the study is to identify the cytotoxic effect of Acacia nilotica assisted strontium nanoparticles.
Method: In this study , a plant of Acacia Nilotica and strontium nanoparticles was exposed to brine shrimp
Results: strontium nanoparticles synthesized using Acacia Nilotic extract can act as a potential cytotoxic agent. However, the antimicrobial activity of the extract varied with the different bacterial samples. The cytotoxicity of nano- materials and nanocomposites tested against brine shrimps showed minimal lethality. Strontium nanoparticles are previously reported to show potent cytotoxic activities in-vivo/in-vitro and our results are in accordance with their results.
Conclusion: Interestingly it is presumed that acacia Nilotica interceded strontium nanoparticles are strong helpful specialists to be utilized in biomedical applications both in-vivo/in-vitro. Naturally combined strontium nanoparticles show exhibitory different helpful potential which acquires significance presently.

Abstract 196 | PDF Downloads 160

References

1. Shanmugam R, Subramaniam R, Kathirason SG, Ali D, Balusamy SR, Gurusamy A, et al. Curcumin-Chitosan Nanocomposite Formulation Containing Pongamia pinnata-Mediated Silver Nanoparticles, Wound Pathogen Control, and Anti-Inflammatory Potential. Biomed Res Int [Internet]. 2021 Dec 23 [cited 2022 Dec 23];2021. Available from: https://doi.org/10.1155/2021/3091587
2. Rajeshkumar S, Menon S, S, Venkat Kumar, Ponnanikajamideen M, Ali D, Arunachalam K. Anti-inflammatory and Antimicrobial Potential of Cissus quadrangularis-Assisted Copper Oxide Nanoparticles. J Nanomater [Internet]. 2021 Dec 27 [cited 2022 Dec 23];2021. Available from: https://doi.org/10.1155/2021/5742981
3. Website [Internet]. Available from: . https://doi.org/10.1016/j.jphotobiol.2019.111531
4. Website [Internet]. Available from: https://doi.org/10.1155/2021/8511576
5. Uthayasankar D, Roy A, Kumar S, Thangavelu L. Nutmeg oleoresin assisted copper sulphide nanoparticles and its anti-inflammatory activity. J Complement Med Res. 2021;12(4):87.
6. [No title] [Internet]. [cited 2022 Dec 23]. Available from: http://dx.doi.org/10.19070/2377-8075-21000395
7. Ganapathy D, Shivalingam C, Shanmugam R, Sundramoorthy AK, Murthykumar K, Pitchiah S, et al. Recent Breakthrough of Bismuth-Based Nanostructured Materials for Multimodal Theranostic Applications. J Nanomater [Internet]. 2022 Jul 4 [cited 2022 Dec 23];2022. Available from: https://doi.org/10.1155/2022/4944320
8. Rajeshkumar S, Santhoshkumar J, Vanaja M, Sivaperumal P, Ponnanikajamideen M, Ali D, et al. Evaluation of Zebrafish Toxicology and Biomedical Potential of Aeromonas hydrophila Mediated Copper Sulfide Nanoparticles. Oxid Med Cell Longev [Internet]. 2022 Jan 28 [cited 2022 Dec 23];2022. Available from: https://doi.org/10.1155/2022/7969825
9. Ganapathy D, Shanmugam R, Pitchiah S, Murugan P, Chinnathambi A, Alharbi SA, et al. Potential Applications of Halloysite Nanotubes as Drug Carriers: A Review. J Nanomater [Internet]. 2022 Apr 20 [cited 2022 Dec 23];2022. Available from: https://doi.org/10.1155/2022/1068536
10. Nagalingam M, Rajeshkumar S, Balu SK, Tharani M, Arunachalam K. Anticancer and Antioxidant Activity of Morinda Citrifolia Leaf Mediated Selenium Nanoparticles. J Nanomater [Internet]. 2022 May 11 [cited 2022 Dec 23];2022. Available from: https://doi.org/10.1155/2022/2155772
11. Rajeshkumar S. Citrus Lemon Juice Mediated Preparation of AgNPs/Chitosan-Based Bionanocomposites and Its Antimicrobial and Antioxidant Activity. J Nanomater [Internet]. 2021 Oct 6 [cited 2022 Dec 23];2021. Available from: https://doi.org/10.1155/2021/7527250
12. View of In vitro Anti-inflammatory activity of Silymarin/Hydroxyapatite/Chitosan Nanocomposites and its cytotoxic effect using Brine shrimp lethality assay [Internet]. [cited 2022 Dec 23]. Available from: https://doi.org/10.47750/jptcp.2022.874
13. Viswanathan S, Palaniyandi T, Shanmugam R, Tharani, Rajendran BK, Sivaji A. Biomedical potential of silver nanoparticles capped with active ingredients of Hypnea valentiae, red algae species. Part Sci Technol. 2022 Aug 18;40(6):686–96.
14. Website [Internet]. Available from: https://doi.org/10.1515/gps-2021-0060
15. Mohapatra S, Leelavathi, Rajeshkumar, Sakthi S, Jayashri. Assessment of cytotoxicity, anti-inflammatory and antioxidant activity of zinc oxide nanoparticles synthesized using clove andcinnamon formulation - an in-vitro study. J Evol Med Dent Sci. 2020 Jun 22;9(25):1859–64.
16. Aathira CM, Arivarasu L, Rajeshkumar S. Antioxidant and Anti-Inflammatory Potential of Chromium Picolinate Mediated Zinc Oxide Nanoparticle. Journal of Pharmaceutical Research International. 2020 Aug 26;118–21.
17. Website [Internet]. Available from: https://doi.org/10.9734/jpri/2020/v32i2030727
18. Francis T, Rajeshkumar S, Roy A, Lakshmi T. Anti-inflammatory and cytotoxic effect of arrow root mediated selenium nanoparticles. Pharmacogn J. 2020 Sep 15;12(6):1363–7.
19. Website [Internet]. Available from: https://doi.org/10.1007/s12010-021-03712-8.
20. Website [Internet]. Available from: https://doi.org/10.1155/2022/9569226
21. Priyadharshini S, Jeevitha M, Rajeshkumar S, Jayaraman S. Abies webbiana mediated zinc oxide nanoparticles and its anti-inflammatory activity. J Pharm Res Int. 2021 Dec 29;85–93.
22. View of In vitro Anti-inflammatory activity of Silymarin/Hydroxyapatite/Chitosan Nanocomposites and its cytotoxic effect using Brine shrimp lethality assay [Internet]. [cited 2022 Dec 23]. Available from: https://doi.org/10.47750/jptcp.2022.874
23. Nivedha VM, Priyadarshini R, Rajeshkumar S, Sinduja P. Anti-diabetic and Antioxidant Activity of Pterocarpus santalinus and Stevia
Herbal Formulation. J Pharm Res Int. 2021 Dec 29;124–34.
24. Website [Internet]. Available from: https://doi.org/10.47750/jptcp.2022.870
25. Subramanian AK, Prabhakar R, Vikram NR, Dinesh SS, Rajeshkumar S. anti-inflammatory activity of silymarin/hydroxyapatite/chitosan nanocomposites and its cytotoxic effect using brine shrimp lethality assay. J Popul Ther Clin Pharmacol. 2022 Jan 12;28(2):e71–7.
26. Rajeshkumar S, Santhoshkumar J, Jule LT, Ramaswamy K. Phytosynthesis of Titanium Dioxide Nanoparticles Using King of Bitter Andrographis paniculata and Its Embryonic Toxicology Evaluation and Biomedical Potential. Bioinorg Chem Appl [Internet]. 2021 Oct 7 [cited 2022 Dec 23];2021. Available from: https://doi.org/10.1155/2021/6267634
27. Website [Internet]. Available from: https://doi.org/10.1155/2021/1222908
28. Selvaraj A, George AM, Rajeshkumar S. Efficacy of zirconium oxide nanoparticles coated on stainless steel and nickel titanium wires in orthodontic treatment. Bioinformation. 2021 Aug 31;17(8):760–6.
29. Dhanraj G, Rajeshkumar S. Anticariogenic Effect of Selenium Nanoparticles Synthesized Using Brassica oleracea. J Nanomater [Internet]. 2021 Jul 10 [cited 2022 Dec 23];2021. Available from: https://doi.org/10.1155/2021/8115585

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Published

Jun 1, 2023

DOI https://doi.org/10.47750/jptcp.2023.30.13.011

How to Cite

Prateek Veerendrakumar S, Rajeshkumar S, T Lakshmi, & A Jayasree. (2023). Comparative cytotoxic effect of Acacia nilotica and its mediated strontium nanoparticles. Journal of Population Therapeutics and Clinical Pharmacology, 30(13), 118–124. https://doi.org/10.47750/jptcp.2023.30.13.011