Design, Synthesis, And Characterization of Some New Schiff Bases Derivatives for Piperidine, 3-Amino-1,2,4-Triazole-5-Thiolate Salt and Biological Evaluation as Antibacterial Agents
Main Article Content
Keywords
3-amino-1,2,4-triazole-5-thiol, Piperidinium salt, Schiff base, antibacterial activity
Abstract
Schiff bases (MP1-MP10) were synthesized by reacting various benzaldehyde derivatives with 3- amino-1,2,4-triazole-5-thiol in the presence of piperidine, and all compounds were identified using spectroscopy. UV, FIR, GC-Mass, and HNMR for some combinations, as well as measuring melting points. The obtained results matched the suggested structures of the newly synthesized compounds. All prepared compounds (MP1-MP10) were tested for biological activity against four types of Grampositive and Gram-negative bacteria at seven concentrations. The study found that the compound MP1 inhibited all types of bacteria in the first four concentrations.
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4. Geetha, B. M., Brinda, K. N., Achar, G., Małecki, J. G., Alwarsamy, M., Betageri, V. S., & Budagumpi, S. (2020). Coumarin incorporated 1, 2, 4–triazole derived silver (I) N–heterocyclic carbene complexes as efficient antioxidant and antihaemolytic agents. Journal of Molecular Liquids, 301, 112352.
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6. Khairuddean, M., Slaihim, M. M., Alidmat, M. M., Al-Suede, F. S. R., Ahamed, M. B. K., Shah, A. M., & Majid, A. (2020). Synthesis, Characterisation Of Some New Schiff Base For The Piperidinium 4-Amino-5-Substituted-4h-1, 2, 4-Triazole-3-Thiolate, And Their In-Vitro Anticancer Activities. Int. J. Natural Sci. Human Sciences. 1(1), 48-58.
7. Kosikowska, U., Wujec, M., Trotsko, N., Płonka, W., Paneth, P., & Paneth, A. (2020). Antibacterial activity of fluorobenzoylthiosemicarbazides and their cyclic analogues with 1, 2, 4-triazole scaffold. Molecules, 26(1), 170.
8. Liu, Z., Dang, K., Gao, J., Fan, P., Li, C., Wang, H., ... & Qian, A. (2022). Toxicity prediction of 1, 2, 4-triazoles compounds by QSTR and interspecies QSTTR models. Ecotoxicology and Environmental Safety, 242, 113839.
9. Naqvi, A., Shahnawaaz, M., Rao, A. V., Seth, D. S., & Sharma, N. K. (2009). Synthesis of schiff bases via environmentally benign and energy-efficient greener methodologies. E-Journal of Chemistry, 6(S1), S75-S78.
10. Nayarisseri, A. (2020). Most promising compounds for treating COVID-19 and recent trends in antimicrobial & antifungal agents. Current topics in medicinal chemistry, 20(24), 2119-2125.
11. Sayed, M., El-Dean, A. M. K., Ahmed, M., & Hassanien, R. (2017). Synthesis of some new heterocyclic compounds containing indole moiety. European Chemical Bulletin, 6(4), 171-176 .
12. Shi, J., Ding, M., Luo, N., Wan, S., Li, P., Li, J., & Bao, X. (2020). Design, synthesis, crystal structure, and antimicrobial evaluation of 6-fluoroquinazolinylpiperidinyl-containing 1, 2, 4-triazole Mannich base derivatives against phytopathogenic bacteria and fungi. Journal of Agricultural and Food Chemistry, 68(36), 9613-9623.
13. Slaihim, M. M., Al-Suede, F. S. R., Khairuddean, M., Ahamed, M. B. K., & Majid, A. M. S. A. (2019). Synthesis, characterisation of new derivatives with mono ring system of 1, 2, 4-triazole scaffold and their anticancer activities. Journal of Molecular Structure, 1196, 78-87.
14. Soliman, A. I., Sayed, M., Elshanawany, M. M., Younis, O., Ahmed, M., Kamal El-Dean, A. M., ... & Tolba, M. S. (2022). Base-Free Synthesis and Photophysical Properties of New Schiff Bases Containing Indole Moiety. ACS omega, 7(12), 10178-10186.
15. Turky, A., Bayoumi, A. H., Sherbiny, F. F., El-Adl, K., & Abulkhair, H. S. (2021). Unravelling the anticancer potency of 1, 2, 4-triazole-N-arylamide hybrids through inhibition of STAT3: synthesis and in silico mechanistic studies. Molecular Diversity, 25(1), 403-420.
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Published
Jun 12, 2022
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How to Cite
Abeer Hussein Ali, & Mukhlif Mohsin Slaihim. (2022). Design, Synthesis, And Characterization of Some New Schiff Bases Derivatives for Piperidine, 3-Amino-1,2,4-Triazole-5-Thiolate Salt and Biological Evaluation as Antibacterial Agents. Journal of Population Therapeutics and Clinical Pharmacology, 29(02), 193–202. https://doi.org/10.47750/jptcp.2022.971
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