Synthesis of a remarkable new Schiff bases series via an amino-1, 3-diol substrate
Main Article Content
Keywords
1,3-Propanediol; Imine compounds; Piperidine catalysed; Amino alcohol
Abstract
Piperidine catalysed In chemistry, 2-amino-2-methyl-1,3-propanediol's reaction with various aromatic aldehydes, generating Schiff bases and the corresponding 1,3-dioxane. The combination of Schiff bases and 1,3-dioxane compounds were practically separated. The data were then identified utilising relevant Spectroscopic Imaging in the infrared spectrum and nuclear magnetic resonance are only two examples of the, and 13C-NMR spectroscopy, in addition to the GC-MS methodology.
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23. Sharif HM, Ahmed D, Mir H. Antimicrobial salicylaldehyde Schiff bases: Synthesis, characterization, and evaluation. Pak. J. Pharm. Sci. 2015 Mar;28(2):449-55.
2. Ejidike IP, Ajibade PA. Synthesis and in vitro anticancer, antibacterial, and antioxidant studies of unsymmetrical Schiff base derivatives of 4-[(1E)-N-
(2-aminoethyl) ethanimidoyl] benzene-1, 3-diol. Research on Chemical Intermediates. 2016 Aug;42(8):6543-55.
3. Venugopala KN, Jayashree BS. Synthesis of carboxamides of 2′-amino-4′-(6-bromo-3-coumarinyl) thiazole as analgesic and antiinflammatory agents.
Indian Journal of Heterocyclic Chemistry. 2003 Apr 1;12(4):307-10.
4. Vashi K, Naik HB. Synthesis of novel Schiff base and azetidinone derivatives and their antibacterial activity. E-Journal of Chemistry. 2004;1(5):272-5.
5. Kostova I, Saso L. Advances in research of Schiffbase metal complexes as potent antioxidants. Current medicinal chemistry. 2013 Dec 1;20(36):4609-32.
6. Dhar DN, Taploo CL. Schiff-bases and their applications. Journal of Scientific & Industrial Research. 1982 Jan 1;41(8):501-6.
7. DaSilva CM, da Silva DL, Modolo LV, Alves RB, de Resende MA, Martins CV, deFátima Â. Schiffbases: A short review antimicrobiol activitie. J.Advanced
research. 2011 Jan 1;2(1):1-8.
8. Przybylskii P, Huczynskii A, Pyta K, Brzezinski B, Bartl F. Biological,properties of Schifff bases and azoderivatives of phenols. Current Organic Chem..
2009 Jan 1;13(2):124-48.
9. Khalaf MM, Abd El-Lateef HM, Gouda M, Sayed FN, Mohamed GG, Abu-Dief AM. Design, Structural Inspection and Bio-Medicinal Applications of Some Novel Imine Metal Complexes Based on Acetylferrocene. Materials. 2022 Jul 12;15(14):4842.
10. Pestov A, Bratskaya S. Chitosan and its derivatives as highly efficient polymer ligands. Molecules. 2016 Mar 11;21(3):330.
11. Nepali K, Sharma S, Sharma M, Bedi PM, Dhar KL. Rational approaches, design strategies, structure activity relationship and mechanistic insights for
anticancer hybrids. European journal of medicinal chemistry. 2014 Apr 22;77:422-87.
12. Kabeer H, Hanif S, Arsalan A, Asmat S, Younus H, Shakir M. Structural-dependent N, O-donor imineappended Cu (II)/Zn (II) complexes: Synthesis,
spectral, and in vitro pharmacological assessment. ACS omega. 2020 Jan 6;5(2):1229-45.
13. Soroceanu A, Bargan A. Advanced and biomedical applications of Schiff-base ligands and their metal complexes: A review. Crystals. 2022 Oct
12;12(10):1436.
14. Sundaravel K, Suresh E, Palaniandavar M. Synthesis, structures, spectral and electrochemical properties of copper (II) complexes of sterically hindered Schiff base ligands. Inorganica Chimica Acta. 2009 Jan 1;362(1):199-207.
15. Shakir M, Hanif S, Alam MF, Younus H. Molecular hybridization approach of bio-potent CuII/ZnII complexes derived from N, O donor bidentate imine scaffolds: Synthesis, spectral, human serum albumin binding, antioxidant and antibacterial studies. Journal of Photochemistry and Photobiology B: Biology. 2016 Dec 1;165:96-114.
16. Malins LR, deGruyter JN, Robbins KJ, Scola PM, Eastgate MD, Ghadiri MR, Baran PS. Peptide macrocyclization inspired by non-ribosomal imine
natural products. Journal of the American Chemical Society. 2017 Apr 12;139(14):5233-41.
17. Li S, Chen S, Lei S, Ma H, Yu R, Liu D. Investigation on some Schiff bases as HCl corrosioninhibitors for copper. Corrosion Science. 1999 Jul 1;41(7):1273-87.
18. Bhattacharya A, Purohit VC, Rinaldi F. Environmentally friendly solvent-free processes: novel dual catalyst system in Henry reaction. Organic
process research & development. 2003 May 16;7(3):254-8.
19. Khan HY, Maurya SK, Siddique HR, Yousuf S, Arjmand F. New tailored RNA-targeted organometallic drug candidates against Huh7 (Liver) and Du145 (Prostate) cancer cell lines. ACS omega. 2020 Jun 19;5(25):15218-28.
20. Brogden G, Husein DM, Steinberg P, Naim HY. Isolation and quantification of sphingosine and sphinganine from rat serum revealed gender
differences. Biomolecules. 2019 Sep 7;9(9):459.
21. Khairuddean M, Slaihim MM, Alidmat MM, AlSuede FS, Ahamed MB, Shah AM, Majid A. SYNTHESIS, CHARACTERISATION OF SOME NEW SCHIFF BASE FOR THE PIPERIDINIUM 4- AMINO-5-SUBSTITUTED-4H-1, 2, 4-TRIAZOLE3-THIOLATE, AND THEIR IN-VITRO ANTICANCER ACTIVITIES. Int. J. Natural Sci. Human Sciences.. 2020;1(1):48-58.
22. Slaihim MM, Al-Suede FS, Khairuddean M, Ahamed MB, Majid AM. Synthesis, characterisation of new derivatives with mono ring system of 1, 2, 4-triazole scaffold and their anticancer activities. Journal of Molecular Structure. 2019 Nov 15;1196:78-87.
23. Sharif HM, Ahmed D, Mir H. Antimicrobial salicylaldehyde Schiff bases: Synthesis, characterization, and evaluation. Pak. J. Pharm. Sci. 2015 Mar;28(2):449-55.
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Published
Mar 4, 2023
Article Details
How to Cite
Mukhlif Mohsin Slaihim, Hamid J. Mohammad, & Abeer Hussein Ali. (2023). Synthesis of a remarkable new Schiff bases series via an amino-1, 3-diol substrate. Journal of Population Therapeutics and Clinical Pharmacology, 30(2), 249–256. https://doi.org/10.47750/jptcp.2023.1105
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