Review on the neuron damage parameters in patients with end-stage renal disease

Main Article Content

Basim Abd Al-Raheem Twaij
Hussein Kadhem Al-Hakeim
Mazin Fadhil Altufaili

Keywords

Damage, Parameters, Patients, Protien

Abstract

Many studies have found toxic effects on the body and mental state at near and long-term parameters in end-stage renal disease (ESRD) patients of neuronal integrity. Consequently, studying chemical molecules that cause tissue damage to neurons is essential for understanding the mechanism of toxicity and available treatment prospects. Which includes some parameters of myelin basic protein (MBP), ionized calcium-binding adaptor molecule 1 IBA1, calcium-binding protein B (S100B), Glial fibrillary acidic protein (GFAP), neuroepithelial stem cell protein (Nestin), neurofilament light polypeptide (NFL), neuron-specific enolase, T-tau and claudin proteins.
The published papers on changes in neuronal damage final products in ESRD patients were reviewed, and the explanations obtained from previous research were collected. It is concluded from this review that causes an increase in parameters in patients with ESRD lead to neurodegeneration, which leads to severe damage to patients health that requires therapeutic intervention to reduce the harmful effects of parameters on the health of patients.

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