Histological depth of invasion and its correlation in oral squamous cell carcinoma- a retrospective study
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Keywords
Depth of invasion, nodal metastasis, oral squamous cell carcinoma, prognosis, Good health and well being
Abstract
Introduction: Oral squamous cell carcinoma is the most prevalent head and neck tumour, which is also one of the main causes of cancer-specific mortality. The most often impacted area of OSCC is the tongue. Occult nodal metastasis is the most significant indicator for prognosis of early-stage OSCC with a clinically negative neck. It was discovered that depth of invasion was a highly accurate indicator of occult nodal metastasis in OSCC, making it potentially a very valuable tool for predicting the incidence of nodal dissemination and, consequently, prognosis.
Aim: To determine the correlation between depth of invasion and staging of cancer.
Materials and methods: Evaluated the records of OSCC patients retrospectively. Depth of invasion for 30 excision specimens were measured using the magna software. The data was statistically analysed using SPSS software.
Results: DOI less than 5mm can be considered as stage one of OSCC. Similarly DOI of 6-10 mm as stage 2 and 11-15 mm as stage 3. Furthermore, depth of invasion above 16mm can be considered as stage 4 which involves nodal metastasis.
Conclusion: The study concludes that there is correlation between depth of invasion and staging of OSCC, thus DOI can be considered as an important prognosis factor.
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