Improvement Of Quercetin-Loaded Eudrgit L- 100 Nanoparticles Using Factorial Desgin Methadology

Main Article Content

Firas Falih Al-Mamoori
Habibah A. Wahab
Waqas Ahmad

Keywords

nanoparticle, quercetin, experimental design, Box-Behnken, optimization

Abstract

Background: Quercetin is a flavonoid with strong antioxidant properties with a wide range of pharmacological actions. The aim of this study was to see how formulation parameters affected the physicochemical characteristics of quercetin-loaded polymeric nanoparticles so that the formulation might be improved.
Materials and procedures: Nanoprecipitation was used to create the nanoparticles. This study used a Box-Behnken design with three levels and three factors using Eudragit L-100, Pluronic F-68 concentration, and volume of organic solvent as independent variables. Particle size, polydispersity index, and zeta potential as response.
Results: The amount of polymer is the most important factor influencing quercetin-nanoparticle characteristics. Increasing amount of Eudragit L-100 led to an increase in particle size and,. Polydispersity index .As opposed to that, it exhibited a slightly positive influence on zeta potential.
The pluronic concentration had positive effect on particle size and polydispersity index. However, pluronic concentration had an important negative effect on the zeta potential. .The volume of organic solvent had an negative effect on the particle size and zeta potential but positive effect on PDI. Based on An improved formulation was created based on the results, and the experimental values were close to those expected.
Conclusions: Overall, the amount of polymer EDRAGIT L-100 used had the greatest impact on particle size, while the pluronic F-68 concentration had the greatest impact on PDI and zeta potential

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