synthesis and characterization of Pyrimidine from chalcone as a polymeric prodrug with fusidic acid and ZnO and study bioactivity

Main Article Content

Muhsn Ali hazam
Raheem Jameel Mahesein
H. N. K. AL-Salman


chalcone as a polymeric prodrug, Pyrimidine, fusidic acid, ZnO


Pyrimidine was synthesized as a derivative of chalcone, then polymerization of pyrimidine was carried out with fusidic acid and zinc oxide. All the physical properties affecting the construction process, such as Thin-layer chromatography, solubility, the effect of buffer solutions, and temperatures, were studied. Physical diagnostics such as DSC, TGA, and FT-IR were also studied. The study of the
biological activity of the polymer resulting from the interaction of pyrimidine with fusidic acid and zinc oxide, where the study was conducted against three types of bacteria, and the results of the study were compared with the study of fusidic acid alone once and with zinc oxide alone again as a control. The results showed that the process of polymerization of pyrimidine with fusidic acid and zinc oxide gave more effective results against bacteria compared to fusidic acid alone and zinc oxide alone.

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