PERIOPERATIVE OPIOIDS, ANESTHETIC APPROACHES, AND ONCOLOGIC OUTCOMES IN HEAD AND NECK AND MAXILLOFACIAL SURGERY: A SYSTEMATIC REVIEW
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Keywords
Anesthesia, TIVA, Volatile Anesthesia, Opioids, Head and Neck Cancer, Maxillofacial Surgery, Systematic Review
Abstract
Background: Anesthetic techniques and perioperative analgesia may influence cancer biology and long-term oncologic outcomes.
Objective: To evaluate the impact of anesthetic approaches (TIVA, volatile anesthesia, regional anesthesia) and perioperative opioids on oncologic outcomes in head and neck and maxillofacial surgery.
Methods: A systematic review was conducted following PRISMA guidelines. Databases (PubMed, Scopus, Web of Science, Cochrane Library) were searched from inception to January 2023.
Results:Fifteen studies were included. Evidence suggests that propofol-based anesthesia may be associated with improved outcomes, while volatile anesthesia and opioid exposure show inconsistent associations.
Conclusion: Current evidence is inconclusive but suggests anesthesia may influence oncologic outcomes. Further randomized trials are required.
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Dr Sarah Shaukat
Shaheed Zulfiqar Ali Bhutto Medical University, Pakistan MHPE (Scholar)
Dr Tasaddiq Hussion Bhatti
MBBS, MCPS Department of Anaesthesia, MOH, PSBJH, Al Ahsa, KSA
Dr Mahrukh Iqbal
MS (OMFS) Scholar, CHPE, BDS Department of Oral and Maxillofacial Surgery Abbasi Shaheed Hospital, KMDC, Karachi, Pakistan
Dr Nadia Chughtai
Assistant Professor Karachi Metropolitan University, Karachi, Pakistan BDS, MS (Oral and Maxillofacial Surgery), University of Karachi
Dr Muhammad Sana Ullah
MBBS Liaquat university of Medical and Health sciences MHA Student Gannon University, Erie, PA USA
Dr Amber Shams
Liaquat University of Medical & Health Sciences, Jamshoro, Pakistan MBBS, FCPS-II Resident (Obstetrics & Gynaecology) Professional Diploma in Obstetrics & Gynaecology (RCPI, Ireland)
