TO STUDY THE ASSOCIATION OF ABO BLOOD GROUP WITH SYMPTOMATIC COVID-19 CASES
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Keywords
COVID-19, ABO blood group, symptoms, susceptibility
Abstract
Background: Coronavirus disease 2019 (COVID-19) exhibits considerable variability in clinical manifestations. Host biological factors, including the ABO blood group system, have been proposed to influence susceptibility and symptom severity. Aim: To study the association of ABO blood group with symptomatic COVID-19 cases. Materials and Methods: A cross-sectional questionnaire-based study was conducted in the Department of Physiology, Government Medical College, Jammu. On two hundred medical faculty members with RT-PCR-confirmed COVID-19 infection were included. Data regarding ABO blood group and symptoms experienced during illness were collected. Statistical analysis was performed using the chi-square test. Results: Blood groups A and AB were significantly associated with a higher symptom burden and increased frequency of respiratory symptoms. Blood group O showed a relatively protective effect. A statistically significant association was observed between ABO blood group and symptomatic COVID-19 cases (p < 0.05). Conclusion: ABO blood group shows a significant association with symptomatic COVID-19 infection. Blood groups A and AB are associated with increased symptom severity, while blood group O appears to confer relative protection.
References
2. Zhu N, Zhang D, Wang W, Li X, Yang B, Song J, et al. A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med. 2020;382(8):727–733.
3. Huang C, Wang Y, Li X, Ren L, Zhao J, Hu Y, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet. 2020;395(10223):497–506.
4. Ellinghaus D, Degenhardt F, Bujanda L, Buti M, Albillos A, Invernizzi P, et al.Genomewide association study of severe COVID-19 with respiratory failure. N Engl J Med. 2020;383(16):1522–1534.
5. Landsteiner K. Zur Kenntnis der antifermentativen, lytischen und agglutinierendenWirkungen des Blutes. Wien Klin Wochenschr.1901;14:1132–1134.
6. Anstee DJ. The relationship between blood groups and disease. Vox Sang. 2010;98(3 Pt 1):303–317.
7. Mohammadali F, Pourfathollah AA. Association of ABO and Rh blood groups with hepatitis B virus infection. Hepat Mon. 2014;14(4):e17371.
8. Murugananthan K, Subramaniyam S, Kumanan T, Owens L, Ketheesan N, Noordeen F. Blood group AB is associated with severe forms of dengue virus infection. Int J Infect Dis.2018;67:103–105.
9. Degarege A, Medhin G, Animut A, Legesse M, Erko B. Association of ABO blood group and Plasmodium falciparum malaria with anemia in Ethiopian children. Malar J.2012;11:164.
10. Cheng Y, Cheng G, Chui CH, Lau FY, Chan PK, Ng MH, et al. ABO blood group and susceptibility to severe acute respiratory syndrome. JAMA. 2005;293(12):1450–1451.
11. Zhao J, Yang Y, Huang H, Li D, Gu D, Lu X, et al. Relationship between the ABO blood group and the COVID-19 susceptibility. medRxiv. 2020. doi:10.1101/2020.03.11.20031096.
12. Guillon P, Clément M, Sébille V, Rivain JG, Chou CF, Ruvoën-Clouet N, et al. Inhibition of the interaction between the SARS-CoV spike protein and its cellular receptor by anti-histo-blood group antibodies. Glycobiology. 2008;18(12):1085–1093.
13. Gérard C, Maggipinto G, Minon JM. COVID-19 and ABO blood group: another viewpoint. Transfusion. 2020;60(8):1888–1889.
14. Wu Y, Feng Z, Li P, Yu Q. Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clin Infect Dis. 2021;73(2):328–331.
15. Cooling L. Blood groups in infection and host susceptibility. Clin Microbiol Rev. 2015;28(3):801–870.
16. Latz CA, DeCarlo C, Boitano L, Png CYM, Patell R, Conrad MF, et al. Blood type and outcomes in patients with COVID-19. Ann Hematol. 2020;99(9):2113–2118.
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Dr. Shazia
Associate Professor, Department of Physiology, Government Medical College, Jammu, India (mail id: [email protected])
Dr. Siyab Ayoub
Senior resident , Department of Physiology, Government Medical College, Anantnag, India (mail id: [email protected])
Dr. Vanita Sharma
Professor & Head, Department of Physiology, Government Medical College, Jammu, India. (mail id: [email protected])
Dr. Ufaira Ghani
Senior resident , Department of Physiology, Government Medical College, Handwara, India (mail id:
Dr. Henna Bashir
Senior resident , Department of Physiology, Government Medical College, Srinagar, India. (mail id:
