TYPHOID FEVER MASQUERADING AS BONE MARROW GRANULOMA: A DIAGNOSTIC DILEMMA
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Abstract
Typhoid is among the seldomly observed etiology of granuloma in bone marrow despite of very high prevalence of typhoid globally. Here we provide a brief overview of a case of a young male with fever, dry cough, splenomegaly with bicytopenia. Typhoid fever, especially in areas with high prevalence, should be considered as an important differential diagnosis of bone marrow granuloma in patients with prolonged or unexplained pyrexia and in those who have travelled to endemic areas making it important to rule out all other possibilities before starting anti tubercular therapy.
References
2. Huang DB, DuPont HL. Problem pathogens: extra-intestinal complications of Salmonella enterica serotype Typhi infection. The Lancet Infectious Diseases. 2005 Jun;5(6):341–8.
3. Muniraj K, Padhi S, Phansalkar M, Sivakumar P, Varghese RG, Kanungo R. Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review. Case Reports in Infectious Diseases. 2015;2015:1–6.
4. Brackers de Hugo L, Ffrench M, Broussolle C, Sève P. Granulomatous lesions in bone marrow: Clinicopathologic findings and significance in a study of 48 cases. European Journal of Internal Medicine. 2013 Jul;24(5):468–73.
5. Jin Y, Zhang L. Granulomatous inflammation. PathologyOutlines.com website. https://www.pathologyoutlines.com/topic/bonemarrowgranulomatousinflammation.html. Accessed May 2nd, 2024.
6. Jin SY, Lee KW, Kim TS. A Study on the Typhoid Granuloma in the Bone Marrow Biopsy of Patients with Typhoid Fever. Journal of Pathology and Translational Medicine [Internet]. [cited 2024 Apr 8];20(4):462–9.
7. Lee JH, M.D, Lee YH, M.D, Ahn SH, M.D, et al. Granulomatous Bone Marrow Disease. Annals of Laboratory Medicine [Internet]. 1985 Feb 1 [cited 2024 Apr 7];5(1):515–23.
8. Shin BM, Paik IK, Cho HI. Bone marrow pathology of culture proven typhoid fever. Journal of Korean Medical Science. 1994;9(1):57
9. Shamil Nuri Tiremu, Revankar SA, Pai SA. An Unusual Cause of Granulomatous Ileitis – With a Brief History of the Pathology of Typhoid. International journal of surgical pathology. 2017 Oct 16;26(3):240–1.
10. Herman HK, Hampshire KN, Nasim Khoshnam, Khan AA, Jerris R, Abramowsky CR, et al. Suppurative Granulomatous Cholecystitis in a Pediatric Chronic Carrier with Salmonella enterica serotype Typhi: A Case Report and Review of Literature. Fetal and pediatric pathology. 2016 Feb 2;35(2):129–32.
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Dr. Shrey Bhatla
Senior Resident, Department of General Medicine, MM Medical College & Hospital, Kumarhatti, Solan, India
Dr. Anantika Thakur
Assistant Professor, Department of Pathology, MM Medical College & Hospital, Kumarhatti, Solan, India
Dr. Manisha Gulia
Assistant Professor, Department of General Medicine, MM Medical College & Hospital, Kumarhatti, Solan, India
Dr. Shubham Girdher
Senior Resident, Department of General Medicine, Government Medical College, Patiala, India
Dr. Kapil Singh Turan
Senior Resident, Department of General Medicine, MM Medical College & Hospital, Kumarhatti, Solan, India
Dr. Kiran Kumar Singal
Professor, Department of General Medicine, MM Medical College & Hospital, Kumarhatti, Solan, India
