PROTECTIVE ROLE OF FLAXSEEDS (LINUM USITATISSIMUM L.) ON TRIAZOPHOS INDUCED BODY WEIGHT GAIN IN MALE WISTAR RATS
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Keywords
Flaxseeds, Triazophos pesticide, sinusoidal congestion, Wistar albino rats
Abstract
Background: Improper and unplanned handling and application of pesticides, i.e. triazophos in agriculture have caused hepatotoxicity. The need of pesticides to enhance agricultural efficiency is evident, but the high volume of production suggests a significant risk of accidental exposure and potentially life-threatening incidents.
Objective: To determine the effects of Flaxseeds on liver and body weight gain induced by Triazophos pesticide.
Methods: In the current study 24 Wistar albino rats of age: 6-8 weeks and weight 150-200gms were segregated into four equal groups comprising six rats each by Random number Generator. Group A was kept as control group. Groups B, C and D were labelled as experimental. All groups were given standard rat feed and water ad libitum. Group B was given powdered flaxseeds (800mg/kg b.w.) once daily for 21 consecutive days, Group C was given triazophos (8.2mg/kg b.w.) once daily for 21 consecutive days and Group D was given triazophos (8.2mg/kg b.w.) and flaxseeds (800mg/kg b.w.) once daily for 21 consecutive days.
All the selected rats were weighed before the start of the experiment and at the end of the experiment before sacrificing them. Livers of Albino rats were dissected out and their sections were prepared and stained with standard Hematoxylin and Eosin stains to evaluate sinusoidal congestion. Blood samples were taken from the tail of the rats for biochemical evaluation of liver enzymes. On day 22, exactly after 24 hours of administration of the last dose, rats of both the groups, control as well as experimental, were sacrificed under deep anesthesia.
Results: A statistically significant increase with a p value of 0.001, was observed in the body weight as well as liver weight gain in adult male albino rats. Additionally, the antioxidant effect of Flaxseeds has significant ability to ameliorate the effects of Triazophos pesticide.
Conclusion: Daily use of Flaxseeds in our diet can decrease the drastic effects of pesticides on the liver.
References
2. Dharmender Sharma DS, Sangha GK. Triazophos induced oxidative stress and histomorphological changes in liver and kidney of female albino rats.
3. Yadav IC, Devi NL, Syed JH, Cheng Z, Li J, Zhang G, Jones KC. Current status of persistent organic pesticides residues in air, water, and soil, and their possible effect on neighboring countries: A comprehensive review of India. Science of the Total Environment. 2015 Apr 1;511:123-37.
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Arooj Nawaz
Assistant Professor, Anatomy Department, Azra Naheed Medical College, Lahore
Amber Shami
Assistant professor, Anatomy Department, Central Park Medical College. Lahore
Mehreen Salahuddin
Assistant Professor, Anatomy Department, FMH College of Medicine and Dentistry, Lahore
Lubna Shahper
Assistant professor, Anatomy Department, Services Institute of Medical Sciences, Lahore
Huma Jawad
Assistant professor, Anatomy Department, Services Institute of Medical Sciences, Lahore
Huma Jawad
Assistant professor, Anatomy Department, Al-Aleem Medical College, Lahore
Saba Saleem
Associate Professor, Anatomy Department, Central Park Medical College, Lahore
