Assessment of Some Bone Turnover in Chronic Kidney Disease Patients in Tikrit/Iraq
Main Article Content
Keywords
Kidney, Disease, Assessment, Group
Abstract
The present study aimed to assess some bone turnover in chronic kidney disease with and without hemodialysis. 50 individuals were involved in the study and divided into three groups; the first two groups were patients with chronic kidney disease (15 were with hemodialysis, and 15 were without hemodialysis), and the third group involved 20 healthy individuals as a control group. Some bone
turnovers like parathyroid hormone, vitamin D3, insulin-like growth factor-1, osteopontin, fibroblast growth factor-23, and calprotectin were analyzed using serum from all individuals. The serum concentration of parathyroid hormone was significantly lower (P>0.05) in chronic kidney disease with non-hemodialysis compared to chronic kidney disease with hemodialysis group and healthy individuals. While serum concentrations of vitamin D3, insulin-like growth factor, and osteopontin were significantly lower in both chronic kidney disease groups compared to healthy individuals. The serum concentration of fibroblast growth factor showed a non-significant difference (P<0.05) in both chronic kidney disease groups compared to healthy individuals. While serum concentration of calprotectin showed a significant increase (P>0.05) only in the chronic kidney disease without hemodialysis group compared to both other groups.
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12. Kritmetapak K, Pongchaiyakul C. Parathyroid Hormone Measurement in Chronic Kidney Disease: From Basics to Clinical Implications.
International Journal of Nephrology [Internet]. 2019 Sep 17 [cited 2022 Aug 6];2019:1-9. Available from: https://doi.org/10.1155/2019/5496710
13. Dawson-Hughes B, Wang J, Barger K, BischoffFerrari HA, Sempos CT, Durazo-Arvizu RA, Ceglia L. Intra-trial Mean 25(OH)D and PTH
Levels and Risk of Falling in Older Men and Women in the Boston STOP IT Trial. The Journal of Clinical Endocrinology & Metabolism [Internet]. 2022 Jan 12 [cited 2022 Aug 6];107(5):e1932-e1937. Available from: https://doi.org/10.1210/clinem/dgac012.
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from: https://doi.org/10.3390/ijerph15081773
15. Gois P, Ferreira D, Olenski S, Seguro A. Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor? Nutrients [Internet]. 2017 Jun 24 [cited 2022 Aug 6];9(7):651. Available from: https://doi.org/10.3390/nu9070651
16. Wang J, Zhou J, Robertson G, Lee V. Vitamin D in Vascular Calcification: A Double-Edged Sword? Nutrients [Internet]. 2018 May 22 [cited
2022 Aug 6];10(5):652. Available from: https://doi.org/10.3390/nu10050652
17. Naveh-Many T, Volovelsky O. Parathyroid Cell Proliferation in Secondary Hyperparathyroidism of Chronic Kidney Disease. International Journal of Molecular Sciences [Internet]. 2020 Jun 18 [cited 2022 Aug 6];21(12):4332. Available from: https://doi.org/10.3390/ijms21124332
18. Goel N, Pokharna H, Abramowitz MK, Gnanasekaran I. Mineral and Bone Metabolism Disorders in Minority Incident ESRD Patients in
an Inner-City Hemodialysis Unit. Einstein Journal of Biology and Medicine [Internet]. 2016 Mar 2 [cited 2022 Aug 6];30(1&2):16. Available
from: https://doi.org/10.23861/ejbm201530634
19. Adhikary LP, Pokhrel A, Yadava SK, Khadka D, Thakur R. Relation between Serum Intact Parathyroid Hormone Level and Hematocrit in Chronic Kidney Disease Patients. Kathmandu University Medical Journal [Internet]. 2017 Feb 26 [cited 2022 Aug 6];13(3):220-3. Available from: https://doi.org/10.3126/kumj.v13i3.16811
20. Underbjerg L, Sikjaer T, Rejnmark L. LongTerm Complications in Patients With Hypoparathyroidism Evaluated by Biochemical Findings: A Case-Control Study. Journal of Bone and Mineral Research [Internet]. 2018 Feb 14 [cited 2022 Aug 6];33(5):822-31. Available from: https://doi.org/10.1002/jbmr.3368
21. Ghelichi-Ghojogh M, Fararouei M, Seif M, Pakfetrat M. Chronic kidney disease and its health-related factors: a case-control study. BMC
Nephrology [Internet]. 2022 Jan 10 [cited 2022 Aug 6];23(1). Available from: https://doi.org/10.1186/s12882-021-02655-w.
22. Al-Khateeb M. The role of Leptin and Insulin like Growth factor-1 in patients with end stage renal disease under haemodialysis (pre & post
dialysis). Mustansiriya Medical Journal [Internet]. 2013 Apr 14 [cited 2022 Aug 6] 12(1), 53. Available from: https://www.iasj.net/iasj/article/75606.
23. Chen Z, Nilsson E, Lindholm B, Heimbürger O, Barany P, Stenvinkel P, Qureshi AR, Chen J. Low plasma insulin-like growth factor-1 associates with increased mortality in chronic kidney disease patients with reduced muscle strength. Journal of Renal Nutrition [Internet].
2022 Jul [cited 2022 Aug 6]. Available from: https://doi.org/10.1053/j.jrn.2022.06.008.
24. Haffner D, Grund A, Leifheit-Nestler M. Renal effects of growth hormone in health and in kidney disease. Pediatric Nephrology [Internet]. 2021 Jun 18 [cited 2022 Aug 6]. Available from: https://doi.org/10.1007/s00467-021-05097-6
25. Vasilkova VN, Mokhort TV, Pchelin IY, Bayrasheva VK, Naumenko EP, Korotaeva LE, Filiptsova NA. Association between serum
insulin like growth factor-1 (IGF-1) and insulinlike growth factor-binding protein-3 levels and chronic kidney disease in diabetic patients.
Journal of Renal Injury Prevention [Internet]. 2020 Mar 10 [cited 2022 Aug 6];10(1):e05-e05. Available from: https://doi.org/10.34172/jrip.2021.05
26. Dichtel LE, Cordoba-Chacon J, Kineman RD. Growth hormone and insulin-like growth factor I regulation of nonalcoholic fatty liver disease. The Journal of Clinical Endocrinology & Metabolism [Internet]. 2022 Feb 16 [cited 2022 Aug 6]. Available from: https://doi.org/10.1210/clinem/dgac088
27. Gao ST, Lv ZT, Zhou CK, Mao C, Sheng WB. Association between IGF-1 polymorphisms and risk of osteoporosis in Chinese population: a
meta-analysis. BMC Musculoskeletal Disorders [Internet]. 2018 May 10 [cited 2022 Aug 6];19(1). Available from: https://doi.org/10.1186/s12891-018-2066-y
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Mar 13, 2023
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Manar Muyasser Muhammed, & Firas Faris Rija. (2023). Assessment of Some Bone Turnover in Chronic Kidney Disease Patients in Tikrit/Iraq. Journal of Population Therapeutics and Clinical Pharmacology, 30(3), 462–470. https://doi.org/10.47750/jptcp.2023.30.03.048
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