COCAINE TOXICITY AFTER LARYNGOSCOPY IN AN INFANT

Massoud Rezvani; Dawn Hartfield

Massoud Rezvani

The Hospital for Sick Children, Department of Clinical Pharmacology & Toxicology, Toronto, Canada

Dawn Hartfield

Department of Pediatrics, Faculty of Medicine and Dentistry, University of Alberta, Edmonton, Canada

Keywords

Cocaine toxicity, pediatric patients, topical cocaine

Abstract

Iatrogenic cocaine toxicity was observed in a 5.5-month -old male who received intranasal cocaine as a topical anesthetic for laryngoscopy. He became agitated, diaphoretic, tachycardic, and hypertensive shortly following the procedure. To control his signs and symptoms, he required 3 doses of IV lorazepam. Systemic absorption and toxicity can vary amongst individuals, making it difficult to determine appropriate dosing. The maximum dose of 1 mg/kg in children has not been validated and toxicity may appear at a much lower dose in certain individuals. Pediatric patients receiving topical cocaine as an anesthetic must be given the lowest possible dose, and then carefully monitored for signs of systemic absorption.

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PDF

Published

Dec 8, 2018

How to Cite

Rezvani, M., & Hartfield, D. (2018). COCAINE TOXICITY AFTER LARYNGOSCOPY IN AN INFANT. Journal of Population Therapeutics and Clinical Pharmacology, 13(2). Retrieved from https://jptcp.com/index.php/jptcp/article/view/123