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Yaron Finkelstein
Massoud Rezvani
Facundo Garcia-Bournissen
Laila Nurmohamed
Gideon Koren




Administration of pharmaceutical agents to pregnant women is a concern, because of safety issues to both mother and fetus. However, all medication formulations contain many other inactive ingredients in addition to the active drug. In contrast to the extensive research on the safety of active pharmaceutical ingredients in pregnant patients, the fetal safety of the inactive ingredients has been largely ignored. This is likely due to the fact that the inactive ingredients are considered to be in “small amounts” and are believed to be “inert”. However, this is often not the case. Most pharmaceutical preparations will typically contain 5 to 10 times more inactive ingredients in terms of weight versus the actual active ingredients. Therefore, most tablets, for example, are mainly made up of inactive ingredients.

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