PREVALENCE OF MIGRAINE IN PATIENTS WITH HYPOMAGNESEMIA: A STUDY OF MAGNESIUM DEFICIENCY IN DIET

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Keywords

Migraine, Hypomagnesemia, Serum Magnesium, Headache Disorders, Trace Elements

Abstract

Objective: To determine the frequency of hypomagnesemia among patients presenting with migraine at a tertiary care hospital.


Methods: This descriptive cross-sectional study was conducted at the Outpatient Department of Neurology, Nishtar Medical College/Hospital, Multan, Pakistan, from May 16, 2019, to November 16, 2019. A total of 151 adult patients aged 20–60 years diagnosed with migraine were enrolled using non-probability consecutive sampling. Venous blood samples were collected to measure serum magnesium levels. Hypomagnesemia was defined as serum magnesium <1.3 mEq/L.


Results: Out of 151 patients, 71 (47%) were found to have hypomagnesemia. Female patients were more commonly affected, accounting for 62% of the hypomagnesemic cases. There was a statistically significant association between diabetes and hypomagnesemia (p=0.047). No significant associations were observed between hypomagnesemia and age, duration of migraine, obesity, or residential status.


Conclusion: Nearly half of the migraine patients had hypomagnesemia, highlighting the need for routine screening of serum magnesium levels in migraineurs. Further interventional studies are needed to assess whether magnesium supplementation can reduce the frequency and severity of migraine attacks.

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References

1. Steiner TJ, Birbeck GL, Jensen RH, Katsarava Z, Stovner LJ, Martelletti P. Headache disorders are third cause of disability worldwide. J Headache Pain . 2015;16:58.
2. Vos T, Barber RM, Bell B, et al. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013. Lancet . 2015;386(9995):743–800.
3. Millichap JG. Acute treatment regimens for migraine in the ED. Pediatr Neurol Briefs . 2015;29(3):23.
4. Gonullu H, Gonullu E, Karadas S, et al. The levels of trace elements and heavy metals in patients with acute migraine headache. J Pak Med Assoc . 2015;65(7):694–7.
5. Mauskop A, Altura BM. Role of magnesium in the pathogenesis and treatment of migraines. Clin Neurosci . 1998;5(1):24–7.
6. Lin QF, Xia QQ, Zeng YL, et al. Prevalence and clinical features of migraine in China: a population-based study. J Headache Pain . 2016;17:86.
7. Messali A, Sanderson JC, Blumenfeld AM, et al. Direct and indirect costs of chronic and episodic migraine in the United States. Headache . 2016;56(2):306–22.
8. Rezaei AA, Shamsaei F, Rezaei N. Personality characteristics in patients with migraine headaches. Pak J Med Sci . 2006;22(4):480–2.
9. Abbasi SQ. Serum probrain natriuretic peptide in migraine patients. Pak J Physiol . 2016;12(4):21–3.
10. Chasapi S, Tzavara C, Gerothanassis IP, Magoulas A, Theocharis SE. Magnesium and migraine: A review. Nutrients . 2020;12(10):3098.
11. Idrees M, Khan I, Irfan M, Sarwar R. Frequency of anxiety and depression in patients with migraine. J Med Sci . 2010;18(4):172-4.
12. Assarzadegan F, et al. Serum magnesium levels in Iranian migraine patients. Iranian Journal of Neurology , 2017.
13. Barbagallo M, Dominguez LJ. Magnesium, aging, and age-related diseases. Biological Trace Element Research . 2010;138(1-3):239-46.
14. Song Y, et al. Magnesium intake and risk of type 2 diabetes: Meta-analysis of observational studies and randomized trials. Journal of General Internal Medicine . 2006;21(10):1021–9.
15. Facchinetti F, et al. Oral magnesium successfully relieves premenstrual mood changes. Obstetrics & Gynecology . 1991;78(1):177–81.