FREQUENCIES OF BLEEDING DISORDERS IN CHILDREN PRESENTING TO PEDIATRIC DEPARTMENT OF A TERTIARY CARE HOSPITAL

Abstract

Background: bleeding disorder are very common in children which occurs due to multiple factors.

Objective: the aim of this study was to find out the frequencies of bleeding disorders in children presenting to pediatric Department of a Tertiary Care Hospital.

Material and method: The present study was carried out at the department of Pediatrics Gambat Institute of medical and health sciences from January 2018 to June 2018 after taking approval from the research committee of the hospital.  A total of 116 Children and neonates  (day 1 to 12) years  with a suspected bleeding tendency or a family or personal history of congenital bleeding disorders were included in the study, as confirmed by the relevant laboratory tests. Parents or legal guardians gave their informed permission. A thorough clinical examination and history were documented.  All patients had baseline laboratory tests performed on the same day, including complete blood counts, bleeding times, prothrombine times, APTTs, fibrinogen, and blood groupings.  A vascular wall defect was thought to be the source of the bleeding if the coagulation profile was determined to be normal. Schonlen Henock A skin biopsy confirmed purpura. The frequencies and percentages of each qualitative characteristic were examined. For quantitative factors such as age, the mean plus standard deviation was computed. Tables were used to display the findings. The statistical software SPSS version 16 for Windows was used to analyze all of the data.

Results: A total 117 individuals with bleeding disorders were examined in this study .the mean age of the study participants was 06.6884 ± 4.4823 (ranged day 1 up to 12) years. Out of the 56(47.86%) patients who had clotting factor defects, the etiology of coagulative disorders revealed that 17 (14.5%) of them had hemorrhagic disease of the newborn, 15 (12.8%) had diarrhea, 5 (4.2%) had liver parenchymal disease, 5 (4.2%) had DIC, 2 (1.7%) had biliary atresia, 6 (5.1%) had hemophilia "A," 3 (2.5%) had von Wille brand disease, and 3 (2.5%) had factor VII deficiency, respectively. 52 (44.4%) patients had bleeding from thrombocytopenia, 21 (17.9%) had aplastic anemia, 11 (9.4%) had idiopathic thrombocytopenic purpura , 9 (7.5%) had acute lymphocytic leukaemia, 7 (5.9%) had megaloblastic anemia, and 4 (3.4%) had infection-induced thrombocytopenia. Nine cases (7.6%) had vessel wall defects.

Conclusion: The current study concluded that among bleeding disorders the most common was clotting factor deficiencies, followed by platelet and vascular wall problems, respectively.