STUDY OF THE EFFECT OF NOVEL COPROCESSED EXCIPIENTS ON THE FLOW PROPERTIES AND COMPACTIBILITY OF A TABLET BLEND

Abstract

The development of reliable tablet formulations relies heavily on the choice of excipients, as these materials influence both the manufacturing process and the final quality of the product ^[9,10,42]. Conventional single excipients often present limitations, since they may not simultaneously provide desirable flowability, compressibility, and disintegration ^[2,6,46]. To overcome these challenges, co-processed excipients (CPEs) have emerged as innovative multifunctional materials that integrate the advantages of two or more excipients into a single system ^[8,23,59]. Recent research demonstrates that novel CPEs such as silicified microcrystalline cellulose (ProSolv® SMCC), Cellactose®, CombiLac®, and mannitol–starch combinations significantly enhance powder flow, packing uniformity, and bonding strength during compression ^{[14,16,17,18,35].} These improvements lead to tablets with superior mechanical strength, reduced elastic recovery, and more consistent quality attributes ^[15,38]. Furthermore, advances in processing techniques including spray drying, granulation, and particle surface modification have further boosted the functionality of CPEs, making them especially well-suited for direct compression and the development of fast-disintegrating dosage forms ^{[26,31,44,45].}Overall, CPEs represent a practical solution to the drawbacks associated with conventional excipients, offering better processability, lower sensitivity to lubricants, and greater formulation flexibility for modern oral solid dosage forms. ^[25,29,60]