ASSESSMENT OF SERUM FERRITIN LEVEL IN THYROID PATIENTS
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Keywords
Hypothyroid; hyperthyroid: serum ferritin; thyroid stimulating hormone (TSH); free thyroxine.
Abstract
Background:
The thyroid gland is an important hormone gland that regulates metabolism, growth, and development in humans. The thyroid gland is a bilobed endocrine gland that secretes two vital hormones: thyroxine (T4) and triiodothyronine (T3). The production and release of these hormones are regulated by the thyroid-stimulating hormone (TSH) from the pituitary gland. Iron is an essential element for the normal functioning of the thyroid gland. In the body, iron is stored in the form of ferritin. Thyroid hormone release is regulated by the amount of iodine in the body.
Objective:
- To find the correlation of serum ferritin with TSH and FT4 levels in thyroid patients.
MATERIAL And METHODS: This study was performed in 100 Thyroid Patients attending Endocrine OPD in Government Mohan kumaramangalam medical college and hospital and 5ml of venous blood sample will be collected and analysed TSH, FT4, and ferritin in fully automated hormone analyser (Eclia). The statistical analysis was performed using SPSS version 16.
Results: On analyzing the thyroid status and ferritin levels 66% of hypothyroid patient had low ferritin levels which is highly significant (p-value ≤ 0.001). A significant negative correlation was found between TSH and serum ferritin in hypothyroid patients.
Conclusion: This suggests that hypothyroid patients had higher levels of TSH and lower levels of serum ferritin and that there is a negative correlation between TSH and serum ferritin in hypothyroid patients. Hence, the estimation of serum ferritin concentration among hypothyroid patients could be useful in the evaluation of thyroid hormone status.
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Dr. S. Uma Maheswari
Associate professor, Department of Biochemistry, Government Tiruppur Medical College Hospital, Tiruppur, Tamil Nadu, India
Dr. N. Vijayabanu
Associate professor, Department of Biochemistry, Government Namakkal Medical College Hospital, Namakkal, Tamil Nadu, India
Dr. G. Poongodi
Associate professor, Department of Biochemistry, Government Medical College Hospital The Nilgris, Tamil Nadu, India