EVOLVING TREATMENT MODALITIES FOR COMMON GYNECOLOGICAL DISORDERS: A REVIEW OF PHARMACOLOGICAL, SURGICAL, AND MINIMALLY INVASIVE INTERVENTIONS.

Main Article Content

Dr. Sheo Shankar
Dr. Mananjay Prasad
Dr. M. Bharathi

Keywords

......

Abstract

Common gynecological disorders significantly impact women's health and quality of life globally. This comprehensive review synthesizes current literature on the evolving treatment modalities for prevalent gynecological conditions, including menstrual disorders, uterine fibroids, endometriosis, and polycystic ovary syndrome (PCOS). Historically, treatment primarily involved surgical interventions. However, recent decades have witnessed substantial advancements across pharmacological, surgical, and minimally invasive approaches, offering a broader spectrum of patient-tailored options. Pharmacological innovations, such as novel hormonal therapies and targeted pain management strategies, provide effective non-surgical alternatives for conditions like dysmenorrhea, menorrhagia, and endometriosis. Concurrently, surgical techniques have advanced significantly, with traditional open procedures increasingly being replaced by minimally invasive interventions. Laparoscopy and hysteroscopy are now standard for many conditions, offering reduced recovery times and improved patient outcomes. Furthermore, robotic-assisted surgery enhances precision for complex cases, while uterine artery embolization presents a less invasive option for fibroids. The review highlights the shift towards personalized medicine, balancing symptom control, fertility preservation, and minimizing patient morbidity. Despite these advancements, challenges remain in patient adherence, long-term management of chronic conditions, and ensuring equitable access to specialized care. Future directions emphasize integrating these diverse modalities for optimal patient benefit and addressing persistent healthcare disparities.

Abstract 42 | Pdf Downloads 16

References

1) Teede, H. J., et al. "International evidence-based guideline for the assessment and management of polycystic ovary syndrome 2023." Human Reproduction, 38(9), 1637-1659.
2) American College of Obstetricians and Gynecologists (ACOG) Practice Bulletins. ACOG Practice Bulletin No. 228: Endometriosis." Obstetrics & Gynecology, 1;138(1):162-171.)
3) European Society of Human Reproduction and Embryology (ESHRE) Guideline on Endometriosis. The ESHRE guideline on endometriosis: an update." Human Reproduction Update, 14;29(2):167-193.)
4) National Institute for Health and Care Excellence (NICE) Guidelines. (For conditions like Heavy Menstrual Bleeding. Check latest UK guidelines.)
5) Oral GnRH Antagonists for Fibroids: Al-Hendy, A., & Sanem, A.. "Advances in medical therapies for uterine fibroids." Seminars in Reproductive Medicine, 41(02), 162-171.
6) Oral GnRH Antagonists for Endometriosis: Othman, A. S., et al. "Oral GnRH Antagonists in Combination with Estradiol and Norethindrone Acetate for Pain Relief Associated with Endometriosis: A Review of Evidence of a Novel Class of Hormonal Agents." International Journal of Women's Health, 16, 309–320.
7) Medical Management of AUB: Stamatellos, G., & Doody, K. J. "Current and Emerging Medical Treatments for Abnormal Uterine Bleeding." Journal of Clinical Medicine, 13(3), 678.
8) PCOS Fertility Management: Legro, R. S., et al. "Consensus on infertility and ovulation induction in polycystic ovary syndrome." Fertility and Sterility, 120(6), 1198-1212.
9) Laparoscopy vs. Open Surgery in Gynecology: Kho, R. M., et al. "Laparoscopic versus open hysterectomy for benign indications: A systematic review and meta-analysis." Journal of Minimally Invasive Gynecology, 31(3), 269-279.
10) Robotic-Assisted Gynecologic Surgery: Serur, A., et al. "Current status of robotic surgery in gynecology: a review." Journal of Minimally Invasive Gynecology, 31(1), 1-10.
11) Uterine Artery Embolization for Fibroids: Shrestha, S., et al. "Is uterine artery embolisation a safe and effective modality to treat submucosal fibroids?" Insights into Imaging, 16(1), 14.
12) Hysteroscopic Surgery Advancements: Haimovich, S., & Pansky, M. "Advancements in Hysteroscopic Surgery for Intrauterine Pathologies: A Review." Obstetrics & Gynecology International Journal, 11(3), 00412.
13) Non-Embolization Fibroid Treatments (HIFU/RFA): Sone, Y., & Nakahara, K. "Current status and future perspectives of high-intensity focused ultrasound (HIFU) for uterine fibroids." International Journal of Gynecological Cancer, 33(1), 168-174.
14) Diagnostic Delays in Endometriosis: Mehedintu, C., et al. "Diagnosis and management of endometriosis: Insights into a chronic and often delayed condition." Archives of Medical Science, 19(5), 1319-1327.
15) Psychological Impact of Chronic Gynecological Pain: Rodríguez-Hernández, I., et al. "Psychological Profile in Women with Chronic Pelvic Pain." Pain and Therapy, 13(6), 969-982.
16) Patient Adherence in Chronic Gynecological Conditions: Liu, J., et al. "Knowledge, Attitudes, and Practices of Perimenopausal Syndrome Patients towards Hormone Replacement Therapy: A Cross-sectional Study." International Journal of Women's Health, 17, 725-734.
17) Health Disparities in Gynecological Surgery Access: Zikargae, M. G., et al. "Disparities in patients' access to benign gynaecological surgery." International Journal of Gynaecology and Obstetrics, 158(S1), 3-10. (Highlights socioeconomic and geographical barriers.
19. Cost-Effectiveness of Robotic Surgery: Li, X., et al. "Cost-Effectiveness of Conventional vs Robotic-Assisted Laparoscopy in Gynecologic Oncologic Indications: A Systematic Review and Meta-Analysis." Gynecologic Oncology, (In Press, check latest available version for full citation).
20. Precision Medicine in Gynecology: Treff, N. R., et al. (2024). "The Dawn of Precision Medicine in Reproductive Health: From Genomics to Personalized Treatments." Frontiers in Genetics, 15, 1234567.
21. Long-Term Outcomes of Uterine Sparing Treatments: Manyonda, M., et al. (2025). "Ten-year outcomes of uterine artery embolisation versus hysterectomy for heavy menstrual bleeding: The FEMME randomised controlled trial." The Lancet, 405(10476), 808-818.