EVALUATING THE RELATIONSHIP BETWEEN SALIVARY BIOMARKERS AND THE CLINICAL EFFECTIVENESS OF RESTORATIVE DENTAL MATERIALS
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Keywords
Salivary Biomarkers, Clinical Effectiveness, Restorative Dental Materials
Abstract
Introduction: The pursuit of long-lasting, biocompatible, and clinically successful restorative materials remains a fundamental goal in restorative dentistry.1 Advances in material sciences have yielded a broad array of dental restoratives ranging from composite resins and glass ionomer cements to high-performance ceramics each designed to restore function and aesthetics while minimizing biological incompatibility
Objective: This study aims to investigate the relationship between salivary biomarkers and the clinical effectiveness of various restorative dental materials. By identifying biochemical markers in saliva associated with inflammation, tissue response, and oral health status, the research seeks to establish a potential correlation with the performance and longevity of dental restorations.
Methods: A cohort of patients receiving restorative treatments using composite resins, glass ionomer cements, and ceramic-based materials were monitored over a 12-month period. Saliva samples were collected at baseline and at regular follow-ups to assess levels of biomarkers such as matrix metalloproteinases (MMPs), C-reactive protein (CRP), interleukins (IL-1β, IL-6), and oxidative stress markers. Clinical evaluations included assessments of marginal integrity, postoperative sensitivity, secondary caries, and restoration failure.
Results: Preliminary findings suggest a significant association between elevated levels of inflammatory biomarkers and reduced clinical success of certain restorative materials, particularly in patients with poor oral hygiene or systemic inflammatory conditions. Ceramic restorations showed the least biomarker-associated degradation, while resin-based composites demonstrated greater variability in outcomes linked to biomarker fluctuations.
Conclusion: Salivary biomarkers may serve as valuable non-invasive indicators for predicting the clinical performance of restorative dental materials. Integration of salivary diagnostics into routine dental practice could enhance material selection and personalized treatment planning, ultimately improving long-term restorative outcomes.
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Dr. Hina Ashraf
Assistant Professor Dental Materials, Ayub Medical College, Dental Section, Abbottabad, Pakistan
Dr. Laiba Khalid
Resident Oral Biology, KMU, Peshawar, Pakistan.
Dr. Sana Ikram
Associate Professor Oral Biology, Shahida Islam Dental College, Lodhran, Pakistan.
Dr. Muhammad Arsalan Raffat
Associate Professor and Head of the Oral Pathology Department, Faculty of Dentistry, Shahida Islam Medical Complex, Lodhran, Punjab
Dr. Ambreen
Demonstrator Oral pathology, KMU-IDS, Kohat, Pakistan
Dr. Syeda Faiza Gillani
Lecturer, KMU-IDS,Kohat, Pakistan