ROLE OF CHOLESTEROL CONTENT IN ENHANCING THE STABILITY OF LIPOSOMAL DRUG CARRIERS
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Keywords
: Liposomal stability, Cholesterol, Drug delivery systems, Encapsulation efficiency, Lipid bilayer rigidity
Abstract
Abstract
Liposomal drug carriers have emerged as a promising tool in targeted drug delivery, offering enhanced bioavailability and controlled release. However, their stability under physiological and storage conditions remains a critical challenge. Cholesterol, a key component in liposomal formulations, plays a pivotal role in stabilizing the lipid bilayer by modulating membrane rigidity and fluidity. This study investigates the effect of varying cholesterol content on the stability of liposomal formulations, focusing on parameters such as particle size, zeta potential, encapsulation efficiency, and leakage under stress conditions. Liposomes were prepared with different cholesterol-to-lipid molar ratios and characterized using dynamic light scattering (DLS), transmission electron microscopy (TEM), and high-performance liquid chromatography (HPLC). Stability was assessed under oxidative stress, freeze-thaw cycles, and different storage temperatures. The results demonstrate that an optimal cholesterol content significantly enhances liposomal stability by reducing leakage and preserving structural integrity, with a notable improvement in encapsulation efficiency and resistance to stress conditions. These findings highlight the critical role of cholesterol in designing robust liposomal drug carriers and provide valuable insights for their application in pharmaceutical formulations.
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Arpana Maurya
Assistant Professor,HRIT University, Ghaziabad
Anjali Bharadwaj
Professor, Venkateshwara University, Gajraula.
Mukesh Bansal
Assistant Professor, RKGIT College of Pharmacy,
Birender Singh
Assistant Professor, Hindu college of Pharmacy, Delhi-NCR, Sonipat -131001 Haryana
Sachin Sharma
Assistant Professor, Adhunik Institute of Education and Research, Ghaziabad