COMPARATIVE EFFICACY OF MINDFULNESS-BASED INTERVENTIONS IN PREVENTING DEPRESSION RELAPSE: A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS
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Keywords
Mindfulness-Based Cognitive Therapy, depression relapse, systematic review, meta-analysis, cognitive behavioral therapy, antidepressants, mindfulness-based interventions
Abstract
Background: Depression relapse presents a substantial global health challenge because people commonly experience new depressive episodes following the treatment of both medications and psychological therapy. The mindfulness based interventions (MBIs) particularly Mindfulness Based Cognitive Therapy (MBCT) have gained wide research attention as treatment alternatives or supplemental approaches to conventional treatments. The specific comparison between MBIs and standard therapy practices regarding relapse prevention continues to be examined by researchers.
Objectives: This research analyzes the effectiveness of MBIs while focusing on MBCT specifically in depression relapse prevention versus traditional treatments of CBT and pharmacotherapy and usual care.
Methodology: This research utilized a systematic database search which included both PubMed and PsycINFO and Web of Science and Embase platforms to locate randomized controlled trials (RCTs) and meta-analyses published since 2000. The study included research that evaluated MBCT or other MBIs against alternative treatments for depression relapse prevention. Researchers extracted relevant information about relapse statistics along with symptom changes and extended treatment success from the studies. A random-effects model served for conducting meta-analysis to evaluate the collective effect size of MBIs regarding relapse prevention.
Results: The research included 23 different studies involving more than 4500 participants. Research outcomes through meta-analysis show MBCT provides better depression relapse avoidance than standard treatment with a calculated risk ratio of 0.68 and 95% confidence interval range between 0.56 and 0.81 at p values under 0.001. The research suggests MBCT and maintenance antidepressant treatment show equivalent outcomes but MBCT potentially provides better results for long-term prevention of depressive relapse. Research confirmed that MBCT can maintain comparable effectiveness against CBT when preventing relapse through its capability to decrease persistent symptoms while enhancing emotional control.
Conclusion: The Mindfulness-Based Interventions including MBCT show effectiveness in depression prevention because they function as a promising substitute for preventive medication. The presented evidence promotes MBCT as a valuable intervention for inclusion in clinical guidelines that manage recurrent depression. Upcoming studies need to concentrate on improving delivery methods of interventions along with finding precise patient clusters that gain maximum benefits from MBIs.
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Asma Mohammad
University of Sharjah
Nadiya Banu
Rak Medical and Health Sciences University, Ras Al Khaimah, UAE
Mohammed Rahim Hossain
Kuwait Hospital Sharjah, UAE
Kholod Haj Hussain
Kuwait Hospital Sharjah, UAE
Kiran Shahzadi
Pakistan Institute of Medical Sciences, Islamabad, Pakistan
Fathima Farzana
GSM Medical Centre, Dubai, UAE
Muhammad Soman
CMH Kharian Medical College, Kharian, Pakistan
Timsal Arif
Khawaja Muhammad Safdar Medical College, Sialkot, Pakistan
Lyba Zainab
HITEC Institute of Medical Sciences, Taxila, Pakistan
Muhammad Hasnat Akhtar
CMH Kharian Medical College, Kharian, Pakistan
Meera Al Shamsi
Zayed Higher Organization for People of Determination, Abu Dhabi, UAE
Ahmad Raza Tahir
Shifa College of Medicine/ Shifa International Hospital, Islamabad, Pakistan