THE ROLE OF HISTOPATHOLOGY IN DIAGNOSING EARLY LARYNGEAL CARCINOMA: A CLINICOPATHOLOGICAL STUDY
Main Article Content
Keywords
Laryngeal carcinoma, histopathology, squamous cell carcinoma, early diagnosis, clinicopathological study
Abstract
Introduction: Laryngeal carcinoma frequently appears in the upper aerodigestive tract, and prompt diagnosis is essential for better patient results. Histopathology is the standard method for verifying diagnosis, tumor subtype differentiation, and stage and grade identification.
Objectives: This investigation analyzes the importance of histopathology in premature diagnosis and classification stages of laryngeal carcinoma using clinical and pathological data correlation.
Materials and Methods: The clinical and pathological research occurred at Niazi Medical College Sargodha, Pakistan. Medical providers examined patients with possible laryngeal carcinoma by performing direct laryngoscopic biopsies. The histopathological examination provided information about tumor type grade and precise location.
Results: The examination revealed squamous cell carcinoma in 86.7% of 60 total patients, and this carcinoma typically manifested as well-differentiated. Most tumors began in the glottic region because hoarseness remained the leading symptom for patients. Histopathology has proved effective in detecting frequent and infrequent tumor types.
Conclusion: Early diagnosis of laryngeal carcinoma depends significantly on histopathology to determine appropriate treatment strategies along with patient prognoses.
References
2. Priya, K., 2023. A Cross-Sectional Study on Histopathology of Laryngeal Lesions in a Tertiary Care Center. Online Journal of Health and Allied Sciences, 22(2).
3. Zidar, N., Thompson, L.D., Agaimy, A., Stenman, G., Hellquist, H., Nadal, A., Mäkitie, A.A., Fernando, L., Strojan, P. and Ferlito, A., 2025. The impact of histopathology on prognosis of squamous cell carcinoma of the larynx: can we do better?. Virchows Archiv, pp.1-20.
4. Velez Torres, J.M., Martinez Duarte, E., Diaz-Perez, J.A., Leibowitz, J., Weed, D.T., Thomas, G., Civantos, F.J., Arnold, D.J., Gomez-Fernandez, C. and Rosenberg, A.E., 2021. Primary sarcomas of the larynx: a clinicopathologic study of 27 cases. Head and Neck Pathology, 15, pp.905-916.
5. Balakrishnan, A., 2024. Clinicopathological Study of Cervical Lymphadenopathy. Int J Life Sci Biotechnol Pharma Res, 13, pp.153-161.
6. Chen, Y., Zhou, N., Huang, C., He, X., Wang, X., Tang, H., Wang, W., Wang, J., Li, T. and Guo, D., 2024. EBV-positive small cell neuroendocrine carcinoma of nasopharynx as a probably unique subtype of neuroendocrine carcinoma: a clinicopathologic study of three cases and literature review. Diagnostic Pathology, 19(1), p.101.
7. Abu-Dayeh, A.S., Murshed, K.A., Ammar, A. and Petkar, M., 2023. Primary Sarcomas of the Larynx: A Case Series of Four Different Histopathologic Types. Avicenna Journal of Medicine, 13(04), pp.247-252.
8. Đokanović, D., Gajanin, R., Gojković, Z., Marošević, G., Sladojević, I., Gajanin, V., Jović-Đokanović, O. and Amidžić, L., 2023. Clinicopathological characteristics, treatment patterns, and outcomes in patients with laryngeal cancer. Current Oncology, 30(4), pp.4289-4300.
9. Ye, Q., Hu, L., Jia, M., Deng, L.J. and Fang, S., 2022. Cutaneous verrucous carcinoma: A clinicopathological study of 21 cases with long-term clinical follow-up. Frontiers in Oncology, 12, p.953932.
10. Singh, M., Agrawal, P., Sharma, E., Yadav, J.S., Sethi, C. and Sharma, N., 2025. Expression of CD44 and Its Correlation With Clinicopathological Factors in Oral and Oropharyngeal Carcinoma: A Retrospective Immunohistochemical Study. Cureus, 17(3).
11. Yang, S.M., Wu, M., Han, F.Y., Sun, Y.M., Yang, J.Q. and Liu, H.X., 2021. Role of HPV status and PD-L1 expression in prognosis of laryngeal squamous cell carcinoma. International Journal of Clinical and Experimental Pathology, 14(1), p.107.
12. Salama, M.E.M., Yaqout, M.A.T., Habib, F.M. and Abdel-Salam, S.M., 2023. Topoisomerase IIalpha (TopoIIa) A New Promising Marker for Early Detection of Laryngeal Squamous Cell Carcinoma: An Immunohistochemical Study. Asian Pacific Journal of Cancer Prevention: APJCP, 24(6), p.2135.
13. Alshwayyat, S., Kamal, T.F., Alshwayyat, T.A., Alshwayyat, M., Hanifa, H., Odat, R.M., Rawashdeh, M., Alawneh, A. and Qassem, K., 2024. Machine learning in personalized laryngeal cancer management: insights into clinical characteristics, therapeutic options, and survival predictions. European Archives of Oto-Rhino-Laryngology, pp.1-16.
14. Falco, M., Tammaro, C., Takeuchi, T., Cossu, A.M., Scafuro, G., Zappavigna, S., Itro, A., Addeo, R., Scrima, M., Lombardi, A. and Ricciardiello, F., 2022. Overview on molecular biomarkers for laryngeal cancer: looking for new answers to an old problem. Cancers, 14(7), p.1716.
15. Nasseef, M., Yaseen, E.T., Hamad, W. and Yaseen, M., 2024. The role of human papillomavirus in laryngeal carcinoma using PCR. Polski Przegląd Otorynolaryngologiczny, 13(3), pp.1-6.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Maqbool Ahmed Baloch
Associate Professor, Department of ENT, Niazi Medical College Sargodha, Pakistan
Sabah Kaleem Baloch
Associate Professor, Department of of Pathology, Niazi Medical College Sargodha, Pakistan