STUDY OF THE RED BLOOD CELL INDICES AND COAGULATION PROFILE IN RELATION WITH GLYCATED HEMOGLOBIN (HbA1c) IN TYPE 2 DIABETES MELLITUS INDIVIDUALS AT A TERTIARY CARE HOSPITAL.
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Keywords
Type 2 Diabetes mellitus, Red blood cell indices, MCH, HbA1c, coagulation profile, Glycemic control, thrombotic complications.
Abstract
INTRODUCTION: Diabetes mellitus (DM) is characterized by hyperglycemia(1). The effect of hyperglycemia in altering the aggregation and deformability of RBCs and the reduction in the lifespan of RBCs, is hypothesized to bring changes in these RBC indices. The aim of this study is to assess the red blood cell indices and coagulation impairment in type 2 diabetes mellitus (T2DM) patient, thereby preventing thromboembolic complications.
MATERIAL AND METHODS: This is a hospital-based, cross-sectional study which was conducted at SSIMS and RC hospital, Davanagere from January 2024 to May 2024. 110 cases of T2DM aged above 30 years with HbA1C ≥ 7 were included in this study. RBC count, Hb, HCT, MCV, MCH, MCHC, RDW, HbA1c, PT, INR, aPTT were measured.
RESULT: In this study, males comprised 68.1% of the participants. 45% of participants were in the age group of 51-60 years. Patients with poor glycemic control exhibited low MCH values. The study showed that, the patient with HbA1c >9 showed reduced prothrombin time.
CONCLUSION: This study shows that T2DM patients with HbA1C ≥ 9 have procoagulant state suggesting increased risk of stroke or Myocardial infarction and lower MCH levels in the context of poor glycemic control can serve as an indicator of the risk of developing DM-related vascular complications.
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Dr. Farahanaz Umarfaruk Dhalayat
Junior Resident, Department of General Medicine, S.S Institute of Medical Sciences, Davangere, Karnataka, Email: farahanaz1997@gmail.com
Dr Peersab M Pinjar
Professor, Department of General Medicine, S.S Institute of Medical Sciences, Davangere, Karnataka, Email: drpeersab@gmail.com
Dr Hoysala Kumar D P
Assistant Professor, Department of General Medicine, S.S Institute of Medical Sciences, Davangere, Karnataka, Email: hoysaladp@gmail.com
Dr Pradeep G S
Assistant Professor, Department of General Medicine, S.S Institute of Medical Sciences, Davangere, Karnataka, Email: pradeep16031994@gmail.com