VALIDITY OF MATERNAL SERUM FERRITIN LEVELS AS DIAGNOSTIC TEST FOR PRETERM LABOUR
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Keywords
Preterm Labor, Serum Ferritin, PPROM, Acute Phase Reactants, Subclinical Infections.
Abstract
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. There are various causes of preterm birth including multifetal pregnancy, intrauterine infections, hydramnios, etc. There have been various biochemical markers used to predict preterm labor such as CRH, ILs, CRP, fFN. In this study an attempt has been made to assess serum ferritin as marker of preterm labor, as subclinical maternal infection is responsible for elevated serum ferritin levels.
Aims and objectives
- To assess the validity of maternal serum ferritin levels as diagnostic marker for preterm labor.
- To compare the levels of serum ferritin in term and preterm gestation.
Methods
This study is conducted in the department of Obstetrics and Gynaecology, in Karwar Institute of Medical Sciences for a period of 18 months from August 2022 to January 2024. This was a prospective study. 208 patients were included in the study after satisfying inclusion and exclusion criteria, 104 patients in preterm group and 104 patients in term group. Serum ferritin level of 25ng/ml was taken as cut off. Statistical analysis done and results presented as tables and graphs.
Results
There was a statistically significant association between gestational age and serum ferritin levels at cut off of 25.64ng/ml with a sensitivity, specificity, PPV, NPV and accuracy of 86.5%, 82.7%, 83.3%, 86% and 84.6%.
Conclusion
From our study it can be concluded that serum ferritin levels were significantly higher in preterm group than in term group. There was an increased incidence of preterm labor in those with elevated maternal serum ferritin levels. Hence, serum ferritin can be used as a diagnostic test for predicting preterm labor.
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Dr. Amruta C.
Associate Professor, Department of Obstetrics and Gynecology, Karwar Institute of Medical Sciences, Karwar, Karnataka, India.
Dr. Naresh Pawaskar
Professor & HOD, Department of Obstetrics and Gynecology, Karwar institute of Medical Sciences, Karwar, Karnataka.
Dr. S. Ishwarya
Senior Resident, Department of Obstetrics and Gynecology, Sree Balaji Medical College and Hospital, Chennai, Tamil Nadu, India.