FAMILY HISTORY OF PREMATURE CORONARY ARTERY DISEASE AS AN INDEPENDENT PREDICTOR OF DISEASE SEVERITY: AN OBSERVATIONAL SINGLE-CENTRE STUDY
Main Article Content
Keywords
Pakistan, Gensini score, premature CAD, family history, coronary artery disease, and disease severity.
Abstract
Introduction: Coronary artery disease (CAD) is still a critical and prevalent global health concern, and early onset further increases the threat. It has been established that the history of premature CAD depends on family significantly and is an independent risk factor that determines the development and course of the disease.
Objective: To determine whether a family history of premature CAD is an independent predictor of angiographic disease severity in patients diagnosed with CAD at a tertiary care hospital in Pakistan.
Materials and Method: This cross-sectional study conducted at multi centers including Department of Cardiology, Ayub Teaching Hospital Abbottabad and Hayatabad Medical Complex Peshawar from June 2023 to June 2024. A total of 320 patients being referred for coronary angiography were evaluated in terms of disease severity using the Gensini score. Data were analyzed using SPSS v26.
Results: Individuals with a positive family history had higher Gensini scores (74.2 ± 18.6) and triple-vessel disease rates (39.4%) than those without (21.9%, 58.9 ± 16.3; p<0.001).
References
2- Sharma, Y.P., Vemuri, K.S., Bootla, D., Kanabar, K., Pruthvi, C.R., Kaur, N., Nevali, K.P., Panda, P., Kasinadhuni, G., Uppal, L. and Mohanty, S., 2021. Epidemiological profile, management and outcomes of patients with acute coronary syndrome: multi centre experience from a tertiary care hospital in North India. Indian Heart Journal, 73(2), pp.174-179.
3- Zou, L., Yu, D., Wang, Q., Liu, H., Cun, Y., Li, Y., Qi, J., Mo, X., Peng, W. and Shu, Y., 2025. Timing of venoarterial extracorporeal membrane oxygenation in infant cardiac surgery: a multi-centre retrospective study of clinical outcomes. BMC Cardiovascular Disorders, 25(1), p.191.
4- Sridevi, C., Malani, S., Chaudhary, P.H., Nalawade, D.D., Shokeen, A., Sridevi, C., Chaudhary Sr, P.H., NALAWADE, D.D. and Shokeen Jr, A., 2024. Evaluation of Lipid Profile Management in Coronary Artery Disease Patients on Statin Therapy: A multi-Centre, Retrospective, Observational Study. Cureus, 16(10).
5- Lin, R., Du, N., Feng, J., Li, J., Li, L., Cui, Y., Ning, S., Zhang, M., Huang, G., Wang, H. and Zou, M., 2023. Perioperative EEG background and discharge abnormalities in children undergoing cardiac surgery: a prospective multi-centre observational study. British Journal of Anaesthesia, 131(2), pp.360-372.
6- Palla, A.H., Fatimi, A.S., Virani, S.S. and Fatima, S.S., 2023. Cardiovascular disease risk stratification in the Pakistani population with and without metabolic syndrome: A multi centre cross-sectional study. PLOS Global Public Health, 3(9), p.e0002397.
7- Cesaro, A., Acerbo, V., Scialla, F., Scherillo, G., De Michele, G., Panico, D., Porcelli, G., de Sio, V., Capolongo, A., Sperlongano, S. and Ruggiero, A., 2024. Role of LipoprotEin (a) in CardiovascuLar Diseases and Premature Acute Coronary Syndromes (RELACS Study): impact of Lipoprotein (a) levels on the premature coronary event and the severity of coronary artery disease. Nutrition, Metabolism and Cardiovascular Diseases, p.103843.
8- Forleo, C., Carella, M.C., Basile, P., Carulli, E., Dadamo, M.L., Amati, F., Loizzi, F., Sorrentino, S., Dentamaro, I., Dicorato, M.M. and Ricci, S., 2024. Missense and Non-Missense Lamin A/C Gene Mutations Are Similarly Associated with Major Arrhythmic Cardiac Events: A 20-Year multi-Centre Experience. Biomedicines, 12(6), p.1293.
9- Mohanty, S., Burkhardt, J.D., Di Biase, L., Mohanty, P., Shetty, S.S., Gianni, C., Della Rocca, D.G., Baho, K.K., Morris, T., Mayedo, A. and MacDonald, B., 2023. Best ablation strategy in patients with premature ventricular contractions with multiple morphology: a multi-centre experience. Europace, 25(5), p.euad038.
10- Schick, B., Barth, E., Mayer, B., Weber, C.L., Hagemeyer, T. and Schönfeldt-Lecuona, C., 2021. Prospective, observational, multi-centre cohort study with an independent control group matched for age and sex aimed at investigating the significance of cholinergic activity in patients with schizophrenia: study protocol of the CLASH-study. BMJ open, 11(12), p.e050501.
11- Kiran, G.R., RajKumar, C. and Chandrasekhar, P., 2021. Clinical and echocardiographic predictors of outcomes in patients with peripartum cardiomyopathy: a single centre, six month follow-up study. Indian Heart Journal, 73(3), pp.319-324.
12- Merolla, A., De Lorenzo, R., Ferrannini, G., Renzi, C., Ulivi, F., Bazzigaluppi, E., Lampasona, V. and Bosi, E., 2024. Universal screening for early detection of chronic autoimmune, metabolic and cardiovascular diseases in the general population using capillary blood (UNISCREEN): low-risk interventional, single-centre, pilot study protocol. BMJ open, 14(3), p.e078983.
13- Yu, H., Qiu, Y., Yu, H., Wang, Z., Xu, J., Peng, Y., Wan, X., Wu, X., Jin, R. and Zhou, F., 2021. Anthracycline induced cardiac disorders in childhood acute lymphoblastic leukemia: a single-centre, retrospective, observational study. Frontiers in Pharmacology, 12, p.598708.
14- Han, J., Zhai, W., Wu, Z., Zhang, Z., Wang, T., Ren, M., Liu, Z., Sessler, D.I., Guo, Z. and Meng, L., 2025. Care guided by tissue oxygenation and haemodynamic monitoring in off-pump coronary artery bypass grafting (Bottomline-CS): assessor blind, single centre, randomised controlled trial. bmj, 388.
15- Chowdhary, G.S., Singh, A., Chowdhary, S., Gulati, R., Ahuja, M.S., Bhasin, A. and Padmini, H.S., 2025. An Observational Study of the Incidence and Risk Factors of Multivessel Coronary Artery Disease in Patients with Acute Coronary Syndrome Presenting at a Tertiary Care Hospital India. The Journal of the Association of Physicians of India, 73(1), pp.23-28.
Article Sidebar
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
All articles published in JPTCP are licensed under Copyright Creative Commons Attribution-NonCommercial 4.0 International License.
Dr. Muhammad Musa
Department of Medicine and Allied, Khalifa Gul Nawaz Teaching Hospital, Bannu, Pakistan.
Dr. Farhat Ullah Khan
Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan.
Dr. Naeem Khan
Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan.
Dr. Muhammad Idrees Khan
Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan.
Dr. Ayesha Bibi
Department of Cardiology, Ayub Teaching Hospital, Abbottabad, Pakistan.
Dr. Rahim Dil Khan
Fellow Interventional Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan