A COMPARATIVE STUDY OF SERUM ERRITIN LEVELS AND INSULIN RESISTANCE IN PATIENTS WITH POLYCYSTIC OVARY SYNDROME
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Keywords
Insulin resistance, Polycystic Ovary Syndrome, BMI and hyperandrogenism
Abstract
Introduction: Five to ten percent of women in the reproductive age range suffer with PCOS, one of the most common endocrine disorders. It is a diverse condition marked by hyperandrogenism and persistent anovulation. PCOS is linked to obesity and insulin resistance in addition to ovulatory dysfunction and hyperandrogenic characteristics.
Aims: To analyse the fasting serum levels of ferritin, insulin, iron, glucose and whole blood HbA1c in patients with PCOS and in normal women without PCOS. To measure the BMI, waist circumference and BP in the cases and control groups. To compare the parameters mentioned in cases and controls for any significant statistical differences.
Materials & Methods: Study type Case control study, Outdoor patient of Vani Vilas Hospital , Bangalore, study period from November, 2015 to September, 2017 and total sample size was 60
Result: In Cases Group, 6 (20.0%) patients were ≤25 BMI (kg/m2), 15 (50.0%) patients were 25-30 BMI(kg/m2), 9 (3.0%) patients were ≥30 BMI (kg/m2).In Controls Group, 20 (66.7%) patients were ≤25 BMI (kg/m2), 7 (23.3%) patients were 25-30 BMI(kg/m2), 3 (10.0%) patients were ≥30 BMI (kg/m2).Association of BMI (kg/m2) with cases and controls Group was statistically significant (p=0.0015)
Conclusion: Iron metabolism may be involved in the pathogenesis of PCOS, as indicated by elevated blood ferritin levels and their association with insulin resistance. To enhance metabolic outcomes for PCOS patients, more research is necessary to examine the mechanistic connection and assess treatment approaches that target iron metabolism.
References
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Dr. Portia Dewan
Asst Professor, MD, Dept of Biochemistry, Gouri Devi Institute of Medical sciences and hospital.
Dr. Sandipan Mistry
Asst Professor, MBBS, MD, Dept Of Biochemistry, Gouri Devi Institute of Medical Sciences and Hospital
Dr Aparna Debbarma
Associate professor physiology, Tripura Medical College.