ASSOCIATION OF HYPERURICEMIA WITH THE PRESENCE OF CORONARY ARTERY DISEASE IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY
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Keywords
Elevated uric acid levels, otherwise known as hyperuricemia, had been previously associated throughout the years with ischemic heart disease (IHD), as confirmed by angiography and also with the risk factors urates and elevated urine uric acid to creatinine ratio.
Abstract
Background: Diagnosis of hyperuricemia (increase in level of serum uric acid) has turned out to be a risk factor of CAD that had the power to be an independent cardiovascular disease. However, even some of the known risk factors of CAD, such as hyperuricemia, are still questionable, and the results are inconclusive.
Aim: The aim of this work is to define the relationship between the presence of CAD in patients scheduled for coronary angiography and hyperuricemia.
Methods: The study is a descriptive cross-sectional study of 120 clients referred to coronary angiography at Army Cardiac Hospital Lahore from August 2023 to August 2024. The sample size is calculated using the World Health Organization's (WHO) sample size calculator, taking the 50% frequency of hyperuricemia in CAD patients, the 95% confidence level, and the 5% margin of error. Serum uric acid levels were routinely assessed in the patient and elevated serum uric acid levels were designated hyperuricemia if serum uric acid was above 7 mg/dL in males and above 6 mg/dL in females. CAD significance was quantified by means of the coronary angiographic findings via the Gensini score. We analyzed the results using SPSS software version 25. Chi-square tests were used for categorical variables and logistic regression was used for potential confounders.
Results: Of the 120 patients, 50 percent of them were hyperuricemic overall. Forty-eight (80%) hyperuricemic patients and only 30 (50%) normouricemic patients (< 0.01) presented CAD. Multivariate analysis revealed hyperuricemia as an independent predictor of CAD (OR = 2.5, 95% CI: 1. After controlling for age, gender, hypertension, DM, dyslipidemia, and smoking status, 4-4.15, p = 0.003. Tables and figures describe the distribution of uric acid level, severity of CAD, and risk factors.
Conclusion: The close relationship between the presence and severity of CAD and hyperuricemia in patients with coronarography is demonstrated. Sigmoidal function may be a useful biomarker of risk stratification of CAD by serum urate in man when serum urate is high.
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Ahmad Usman
Department of Cardiology, Army Cardiac Hospital Lahore, Pakistan
Hafiz Mian Muhammad Farhan Siddique
Department of Cardiology, Army Cardiac Hospital Lahore, Pakistan
Bader Javed
Department of Cardiology, Army Cardiac Hospital Lahore, Pakistan
Muhammad Faheem Iqbal Malik
Department of Cardiology, Army Cardiac Hospital Lahore, Pakistan
Omar Asghar
Department of Cardiology, Army Cardiac Hospital Lahore, Pakistan
Taha Asad
Department of Cardiology, Army Cardiac Hospital Lahore, Pakistan