TO COMPARE THE HAEMODYNAMIC EFFECTS OF MIDAZOLAM AND PROPOFOL WHEN USED AS CO-INDUCTION AGENT TO PROPOFOL AND PROPOFOL ALONE

Abstract

Background: Co-induction of anaesthesia, the rationalebehind it being the combination therapy using two or more different drugs with the intention of reaching the same therapeutic goal was heavily criticized for a long time. However, it is accepted today, with the aim of achieving more specific 'target' responses, while minimizing side effects.

Aim: To compare the haemodynamic effects of midazolam and propofol when used as co-induction agent to propofol   and thereby to find out which of these combinations, provides more haemodynamic stability as compared to propofol alone.

Methods: A profile 132 patients were divided into three groups Group A [n=41]: received only propofol for induction of anaesthesia. Group B [n=47]: received midazolam 0.03mg/kg prior to induction of anaesthesia with propofol and Group C [n=44]: received propofol 0.3mg/kg prior to induction of anaesthesia with propofol. The baseline hemodynamic parameters (mean arterial pressure, heart rate and spo2) were recorded. After that parameters were recorded at 1, 2 and 5minutes respectively.  Graphically the data was presented by bar and line diagrams. A P-value of less than 0.05 was considered statistically significant. All P-values were two tailed.

Results: Results: The mean induction dose of propofol was 115.4±15.51 mg in Group A, 73.8±11.89mg in Group B and 81.4±15.34 mg in Group C. The difference was statistically significant with p value of < 0.001. There was statistically significant increase in heart rate from the baseline (P-value<0.01) at 1min, 2min and 5min after induction in Group C. whereas in other two groups (A and B) the difference was statistically insignificant. There was statistically significant increase in MAP in (Group C) from baseline at 2min and 5min after induction (p-value<0.05). Whereas in other two groups (A and B) the difference was statistically insignificant. The mean value of oxygen saturation were comparable at different time intervals among all the three groups .When compared all the values were statistically insignificant at all the times with p value of >0.05. Conclusion: There was better hemodynamic stability in among the study population where coinduction agents were used, it was statistically insignificant. Also the difference among the study population where coinduction agents were used was statistically insignificant so far as hemodynamic stability is concerned.