STUDY OF MEAN PLATELET VOLUME WITH ACUTE MYOCARDIAL INFARCTION

Abstract

Introduction: AMI stays a leading cause of death worldwide. The relationship between Mean Platelet Volume (MPV) and Acute Myocardial Infarction (AMI) has been the focus of several studies, which suggest that elevated MPV levels correlate with worse clinical outcomes in AMI patients.

Materials & Methods: This cace control study was planned to investigate the association between Mean Platelet Volume (MPV) levels and clinical outcomes in AMI patients.

Results: The total sample size comprised 168 participants, with 84 cases (50%) and 84 controls (50%). The mean age of the participants was 57.70 ± 6.52 years, with cases having a mean age of 60.90 ± 6.58 years, and controls having a mean age of 54.50 ± 4.65 years. The platelet count in the case group (2.02 ± 0.47 x10⁵/µL) was significantly lower than in the control group (2.49 ± 0.56 x10⁵/µL), with a p-value of 0.000. Similarly, the Mean Platelet Volume (MPV) was significantly higher in the case group (11.83 ± 1.16 fL) compared to the control group (8.23 ± 0.49 fL), with a p-value of 0.000, indicating a significant difference.In terms of Myocardial Infarction (MI) type, the case group had a variety of diagnoses, including AWMI (45.24%), IWSTEMI (39.29%), and NSTEMI (15.48%), with all controls being normal (p-value = 0.000). ECG changes in the case group included ST elevation (STE) in various leads, such as 2, 3, AVF (39.29%), V1-V3, V2-V5, and V1-V6, while controls presented with normal sinus rhythm (p-value = 0.000).

Conclusion: In conclusion, the elevated MPV in patients with AMI highlights its potential as a novel and easily measurable biomarker for identifying individuals at risk for myocardial infarction and other thrombotic cardiovascular events.