ADVANCED MATERNAL AGE AND PREVALENCE OF CHROMOSOMAL ABNORMALITIES IN CASES OF DISORDERS OF SEX DEVELOPMENT (DSD)
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Abstract
Disorders of Sex Development (DSD) encompass a diverse group of congenital conditions in which the development of chromosomal, gonadal, or anatomical sex is atypical. While DSDs are primarily genetic or sporadic in origin, emerging evidence suggests that advanced maternal age (AMA) may influence the prevalence and expression of chromosomal abnormalities in DSD cases. This review explores the association between AMA and chromosomal anomalies contributing to DSDs, with an emphasis on meiotic nondisjunction, sex chromosome aneuploidy, and diagnostic implications in the prenatal and neonatal period.
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Anushree Pandey
Assistant Professor ,Department of Anatomy, Maharshi Vishwamitra Autonomous State Medical College Ghazipur ,Uttar Pradesh
Dewanshi Mishra
Assistant Professor, Department of Anatomy,Integral Institute of Medical Science and Research, Lucknow, Uttar Pradesh
Rakesh Kumar Verma
Professor, Department of Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh,
India.
Archana Rani
Professor, Department of Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh,
India.
Navneet Kumar
Professor, Department of Anatomy, King George’s Medical University, Lucknow, Uttar Pradesh, India.
S.N. Singh
Professor Department of Pediatrics,King George's Medical University, Lucknow Uttar Pradesh
Sudhir Kumar
Additional Professor, Department of Pediatric Surgery, King George's medical University, Lucknow, Uttar Pradesh